Prof. Gigi Pui-Chi LO
BSc, PhD Adjunct Assistant Professor
P6935, Academic 1,
City University of Hong Kong
(852) 3442 4493
(852) 3442 0549
pclo@cuhk.edu.hk
Education |
1998–2001 |
B.Sc. (Hons.) in Chemistry, First Class |
The Chinese University of Hong Kong |
2001–2005 |
Ph.D. in Chemistry |
The Chinese University of Hong Kong |
Position |
Since 2015 |
Assistant Professor, Department of Biomedical Sciences, City University of Hong Kong, |
Since 2015 |
Adjunct Assistant Professor, Department of Chemistry, The Chinese University of Hong Kong, |
2009 – 2015 |
Research Assistant Professor, Department of Chemistry, The Chinese University of Hong Kong, |
Jan 2007 – Dec 2008 |
Postdoctoral Fellow, Division of Biophysics and Bioimaging, Ontario Cancer Institute, Canada |
Sep 2005 – Jan 2007 |
Postdoctoral Fellow, Department of Chemistry, The Chinese University of Hong Kong |
Research Interests
- Development of Peptide-Conjugated Theranostic Agents for Cancer Treatment
- Exploration of Activatable Photosensitizers for Photodynamic Therapy (PDT) and Antimicrobial PDT.
- Development of Mesoporous Silica Nanoparticles as Versatile Carriers for Photosensitizers
Representative Publications
- “A Phthalocyanine-Peptide Conjugate with High in vitro Photodynamic Activity and Enhanced in vivo Tumour-Retention Property”
M.-R. Ke, S.-L. Yeung, W.-P. Fong, D. K. P. Ng* and P.-C. Lo*
Chem. Eur. J., in press.
- “Photodynamic Molecular Beacons”
P.-C. Lo, J. F. Lovell, and G. Zheng*
Handbook of Biophotonics, J. Popp, V. V. Tuchin, A. Chiou and S. Heinemann (eds.), Wiley-VCH, Vol. 2, 295-304 (2011)
- “Unsymmetrical β-Cyclodextrins-conjugated Silicon(IV) Phthalocyanines as Highly Potent Photosensitizers for Photodynamic Therapy”
J. T. F. Lau, P.-C. Lo, Y.-M. Tsang, W.-P. Fong and D. K. P. Ng*
Chem. Commun., 47, 9657-9659 (2011).
- “Synthesis and in vitro Photodynamic Activities of Pegylated Distyryl Boron Dipyrromethene Derivatives”
H. He, P.-C. Lo,* S.-L. Yeung, W.-P. Fong and D. K. P. Ng*
J. Med. Chem., 54, 3097-3102 (2011)
- “Preparation of Unsymmetrical Distyryl BODIPY Derivatives and Effects of the Styryl Substituents on their in vitro Photodynamic Properties”
H. He, P.-C. Lo,* S.-L. Yeung, W.-P. Fong and D. K. P. Ng*
Chem. Commun., 47, 4748-4750 (2011)
- “Phthalocyanine-Polyamine Conjugates as Highly Efficient Photosensitizers for Photodynamic Therapy”
X.-J. Jiang, S.-L. Yeung, P.-C. Lo,* W.-P. Fong* and D. K. P. Ng*
J. Med. Chem., 54, 320-330 (2011)
- “A pH-Responsive Fluorescence Probe and Photosensitizer Based on a Tetraamino Silicon(IV) Phthalocyanine”
X.-J. Jiang, P.-C. Lo, S.-L. Yeung, W.-P. Fong and D. K. P. Ng*
Chem. Commun., 46, 3188-3190 (2010)
- “Photodynamic Molecular Beacon Triggered by Fibroblast Activation Protein on Cancer-Associated Fibroblasts for Diagnosis and Treatment of Epithelial Cancers”
P.-C. Lo, J. Chen, K. Stefflova, M. S. Warren, R. Navab, B. Bandarchi, S. Mullins, M. Tsao, J. D. Cheng and G. Zheng*
J. Med. Chem., 52, 358-368 (2009)
- “Effects of Peripheral Chloro Substitution on the Photophysical Properties and in vitro Photodynamic Activities of Galactose-Conjugated Silicon(IV) Phthalocyanines”
P.-C. Lo, W.-P. Fong and D. K. P. Ng*
ChemMedChem, 3, 1110-1117 (2008)
- “Highly Photocytotoxic Glucosylated Silicon(IV) Phthalocyanines. Effects of Peripheral Chloro Substitution on the Photophysical and Photodynamic Properties”
P.-C. Lo, C. M. H. Chan, J.-Y. Liu, W.-P. Fong and D. K. P. Ng*
J. Med. Chem., 50, 2100-2107 (2007)
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