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- Chronic endocrine disorders
28 September 2000
- Chronic endocrine disordersCATHAY PACIFIC
SUPPORTS
CUHK Urges for Comprehensive Assessment
& Treatment
for Young Onset Diabetes
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As Hong Kong becomes one of the most cosmopolitan cities in the world,
rapid changes in lifestyle, characterized by overeating, physical inactivity
and psychosocial stress, have unmasked the genetic predisposition of some
individuals to develop diabetes. Inability of an individual to process
the large amount of calories consumed can lead to multiple hormonal abnormalities
resulting in obesity, diabetes and related diseases. Together with the
high prevalence of childhood obesity, all these factors have led to the
increasing prevalence of young-onset type 2 diabetes in Hong Kong Chinese.
It is estimated that 2% of Hong Kong people aged under 40 years have diabetes,
accounting for 20% of the diabetic population.
The Diabetes Care and Research Group at The Chinese University of Hong
Kong has over the last 10 years done extensive research into the local
pattern of diabetes and confirmed the high prevalence of young onset type
2 diabetes and its heterogeneity characterized by multiple risk factors
and complications. Similar trends are also being observed in Mainland
China and many non White populations. In less than 10 years, the prevalence
of diabetes in the 20-40 age group in mainland Chinese has increased by
more than 10 fold. The World Health Organization has estimated that in
contrast to the developed countries where the major increase in prevalence
of diabetes will occur in the elderly subjects, in developing countries,
the major increases will occur in the 40-50 year age group. These alarming
figures carry major socio-economic implications since a 2-3 fold increase
in diabetes prevalence will translate to 500 fold increase in the incidence
of diabetic complications in 10-20 years time such as kidney failure, heart
disease, stroke, blindness and leg amputation.
The conventional classification and treatment guidelines for young onset
diabetes in Caucasians, the majority due to autoimmune destruction of pancreatic
b cells, cannot be readily applied to the local population. Classical autoimmune
Type 1 diabetes remains relatively uncommon, accounting for only 10%, among
local young patients. 50% of these young patients had multiple risk factors
including obesity, albuminuria, high blood pressure and high blood fat
levels. All these are powerful predictors for the future development of
stroke, cardiovascular and renal diseases, which will occur in their late
40 and early 50 years. Unfortunately, despite the high risk nature, many
of these patients are not aware of the progressive nature of the disease
and the importance of comprehensive assessments and optimal management.
In the Prince of Wales Hospital, the CUHK team has developed an infrastructure
and the expertise to provide comprehensive assessment and educational programmes
to these young diabetic patients, which are not widely available in the
community. In 1999, the CUHK Diabetes Care and Research Group established
the Hong Kong Foundation for Research and Development in Diabetes (HKFRDD)
to promote diabetes research and develop innovative programmes to improve
diabetes care. One of these is a self-funded 4-hour comprehensive diabetes
education and assessment programme. In this 4-hour programme, state of
the art methods will be applied to document all complications and risk
factors. These data are computerized and based on existing evidence, diabetologists
will recommended an individualized treatment plan to patients. This is
followed by a 2-hour educational programme to empower patients with their
health information and their rights and roles to achieve optimal diabetes
care. In addition, the hormonal, insulin, genetic and autoimmune status
of these young patients will also be documented as part of the ongoing
research projects to further improve our understanding and to develop novel
treatment for this heterogeneous and complex disease.
In light of the rising incidence of diabetes and its complications worldwide,
the HKFRDD has organized the 2nd Hong Kong Diabetes and Cardiovascular
Risk Factors - East Meets West Symposium on 30 September and 1 October
2000. The symposium provides a forum for local and overseas experts
as well as health care professionals and administrators to discuss and
develop strategies to control the epidemics of diabetes. To further increase
our networking with doctors and nurses in China, the Foundation has also
organised the 1st CUHK Advanced Course in Diabetes Management, which has
been attended by 28 diabetologists from different parts of China to share
experience and develop diabetes health care models in China. Similar courses
are being planned for local doctors and health care professionals to attend
with the objective to improve the standard of diabetes care in our community.
The research programmes have been supported by the Research Grants Council,
Croucher Foundation, Innovation and Technology Fund and CUHK Strategic
Programme. The HKFRDD also received sponsorship from pharmaceutical companies
including Aventis, Celki, Eli Lilly, Knoll, Merck, Novo-Nordisk, Roche,
Servier and Smith-Kline-Beecham to promote diabetes care and research.
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