Prof PANG Chi Pui, Calvin 彭智培講座教授
BSc (Lond), DPhil (Oxon)

S.H. Ho Professor of Visual Sciences
Professor of Ophthalmology and Visual Sciences
Director, CUHK Ophthalmic Research Centre
Director, Shantou University/The Chinese University of Hong Kong Joint Shantou International Eye Centre
Office tel.: (852) 3943-5801
Fax no.: (852) 2715-9490
e-mail: cppang@cuhk.edu.hk

Biography

Prof Pang received a BSc (Hon) in Biochemistry in 1978, University of London, and DPhil in 1982, University of Oxford, on an EP Abraham Research Fund Scholarship, followed by postdoctoral research in Oxford.

In December 1983, Prof Pang was appointed Lecturer in Chemical Pathology at the Chinese University of Hong Kong (CUHK) and became a Professor in 1995. In 1998, Prof Pang moved to the Department of Ophthalmology and Visual Sciences (DOVS). Prof Pang is also advisor to Hong Kong Eye Hospital, Prince of Wales Hospital, Shatin Hospital, Alice Ho Nethersole Hospital and North District Hospital, Hong Kong.

Prof Pang serves as a reviewer for the Wellcome Trust (UK), National Eye Institute (USA), National Medical Research Council (Singapore), Health Research Board (Ireland), Catalan Agency for Health Technology Assessment and Research (Spain), National Science Foundation China and other funding organisations. He is also an academic reviewer, external examiner and honorary or visiting Professor of more than 30 clinical, research and tertiary academic institutions in Hong Kong, mainland China and overseas.

He has contributed 342 publications in SCI international peer review journals and 13 book chapters.


Research Areas

  1. Genomic studies and gene mapping of glaucoma, age-related macular degeneration, polypoidal chroidal vasculopathy, and congenital cataracts.
  2. Molecular genetics of retinoblastoma, diabetic retinopathy, retinal diseases, retinitis pigmentosa, uveitis, corneal dystrophies, and hereditary optic neuropathies.
  3. Biology of ocular stem cells.
  4. Biological effects of herbal molecules on eye diseases.

Representative Publications

  1. Cheng CY, Yamashiro K, Jia Chen L,……, Pang CP, Yoshimura N, Yin Wong T, Khor CC. New loci and coding variants confer risk for age-related macular degeneration in East Asians. Nat Commun. 2015 Jan 28;6:6063.
  2. Qin YJ, Chan SO, Chong KK, Li BF, Ng TK, Yip YW, Chen H, Zhang M, Block NL, Cheung HS, Schally AV, Pang CP. Antagonist of GH-releasing hormone receptors alleviates experimental ocular inflammation. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18303-8.
  3. Shi Y, Gong B, Chen L, Zuo X, Liu X, Tam PO, Zhou X, Zhao P, Lu F, Qu J, Sun L, Zhao F, Chen H, Zhang Y, Zhang D, Lin Y, Lin H, Ma S, Cheng J, Yang J, Huang L, Zhang M, Zhang X, Pang CP, Yang Z. A genome-wide meta-analysis identifies two novel loci associated with high myopia in the Han Chinese population. Hum Mol Genet. 2013 Jun; 22:2325-33.
  4. Verhoeven VJ, Hysi PG, Wojciechowski R, …., Pang CP, Chen LJ, … Saw SM, Bailey-Wilson JE, Stambolian D, Klaver CC, Hammond CJ. Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet. 2013 Mar;45:314-8
  5. Lu Y, Vitart V, Burdon KP,….., Pang CP, Thorsteinsdottir U, Lotery AJ, Hammond CJ, van Duijn CM, Hauser MA, Rabinowitz YS, Pfeiffer N, Mackey DA, Craig JE, Macgregor S, Wong TY. Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Nat Genet. 2013 Feb;45:155-63.
  6. Liu K, Chen LJ, Tam PO, Shi Y, Lai TY, Liu DT, Chiang SW, Yang M, Yang Z, Pang CP. Associations of the C2-CFB-RDBP-SKIV2L locus with age-related macular degeneration and polypoidal choroidal vasculopathy. Ophthalmology. 2013 Apr;120:837-43.
  7. Vithana EN, Khor CC, Qiao C….., Pang CP, Wang N, Aung T. Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma. Nat Genet. 2012 Oct;44:1142-6.
  8. Lee SK, Teng Y, Wong HK, Ng TK, Huang L, Lei P, Choy KW, Liu Y, Zhang M, Lam DS, Yam GH, Pang CP. MicroRNA-145 regulates human corneal epithelial differentiation. PLoS One. 2011;6(6):e21249. Epub 2011 Jun 20.
  9. Chu KO, Chan KP, Wang CC, Chu CY, Li WY, Choy KW, Rogers MS, Pang CP. Green tea catechins and their oxidative protection in the rat eye. J Agric Food Chem 2010 Feb 10;58:1523-34.
  10. DeWan A, Liu M, Hartman S, Zhang S, Liu DTL, Zhao C, Tam POS, Chan WM, Lam DSC, Snyder M, Barnstable C, Pang CP, Hoh J. HTRA serine protease predisposes Asians to age-related macular degeneration. Science Nov 2006;314:989-992.
Academic Faculty