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Prof. JIANG, Li Wen

Address: Room 384, Science Centre, CUHK (Office)
  Room LG101 & LG103, CSLB, CUHK (Lab)
Phone: (852) 3943-6388 (Off) / (852) 3943-6379 (Lab)
Fax: (852) 2603-5646, (852) 2603-5745
E-mail: ljiang@cuhk.edu.hk

 

Education
1996 PhD Simon Fraser University, Canada
1992 MSc University of British Columbia, Canada
1984 BSc South China Agricultural University, China

 

Position
8.2007-present Professor (Department of Biology, The Chinese University of Hong Kong, Hong Kong)
8.2004-7.2007 Associate Professor (Dept of Biology, The Chinese University of Hong Kong, Hong Kong)
8.2000-7.2004 Assistant Professor (Dept of Biology, The Chinese University of Hong Kong, Hong Kong)
1996-2000 Research Associate (Institute of Biological Chemistry, Washington State University, USA)

 

Membership in the following Professional Organizations
The American Society for Plant Biologists
The American Association for the Advancement of Science
The International Society for Seed Science

 

Research Interest
1. Plant cell biology and molecular biology
2. Protein targeting and organelle biogenesis
3. Molecular characterization of plant prevacuolar compartments
4. Molecular mechanism of protein degradation in germinating seeds
5. Plant biotechnolog

 

Representative Publications (* indicates PI and Corresponding Author)

1. Miao, Y.S. and *Jiang, L. (2007) Transient expression of fluorescent fusion proteins in protoplasts of suspension cultured cells. Nature Protocols 2: 2348-2353.
2. Lam, S.K., Tse, Y.C., Robinson, D.G and *Jiang, L. (2007) Tracking down the elusive early endosome. Trends in Plant Science 12: 497-505.
3. Wang, J.Q., Li, Y.B., Lo, S.W., Hillmer, H., Sun, S.S.M., Robinson, D.G. and *Jiang, L. (2007) Protein mobilization in germinating mung bean seeds involves vacuolar sorting receptors and multivesicular bodies. Plant Physiology 143: 1628-1639.
4. Lam, S.K., Siu, C.L., Hillmer, S., Jang, S., An, G., Robinson, D.G. and *Jiang, L. (2007) Rice SCAMP1 defines clathrin-coated, trans Golgi-located tubular vesicular structures as an early endosome in tobacco BY-2 cells. The Plant Cell 19: 296-319.
5. Tse, Y.C., Lo, S.W., Hillmer, S., Dupree, P. and *Jiang, L. (2006) Dynamic response of prevacuolar compartments to Brefeldin A in plant cells. Plant Physiology 142: 1442-1459.
6. Miao, Y., Yan, P.K., Kim, H., Hwang, I. and *Jiang, L. (2006) Localization of GFP fusions with the seven Arabidopsis vacuolar sorting receptors to prevacuolar compartments in tobacco BY-2 cells. Plant Physiology 142: 945-962.
7. Mo, B.X., Tse, Y.C. and *Jiang, L. (2006) Plant prevacuolar/endosomal compartments. International Review of Cytology 253: 95-129. (cover article)
8. Oliviusson, P., Heinzerling, L., Hillmer, S., Hinz, G., Tse, Y.C., Jiang, L. and Robinson, D.G. (2006) Plant retromer: localized to the prevacuolar compartment and microvesicles in Arabidopsis, may interact with vacuolar sorting receptors. The Plant Cell 18: 1239-1252.
9. Wang, J.Q., Miao, Y.S. and *Jiang, L. (2006) Response to Gomord et al: Golgi-bypassing delivery of biopharmaceutical proteins to protein storage vacuole in plant bioreactors. Trends in Biotechnology 24: 147-149.
10. Lo, S.W. and *Jiang, L (2006) Molecular study of prevacuolar compartments in tobacco BY-2 cells. Biotechnology in Agriculture and Forestry 58: 153-166.
11. Oufattole, M., Park, J.H., Poxleitner, M., *Jiang, L and Rogers, J.C. (2005) Selective membrane protein internalization accompanies movement from ER to protein storage vacuole. The Plant Cell 17: 3066-3080.
12. Lam, S.K., Tse, Y.C., Jiang, L , Oliviusson, P., Heinzerling, L., and Robinson, D.R. (2005) Plant prevacuolar compartments and endocytosis. Plant Cell Monographs 1: 37-61.
13. Tse, Y.C., Mo, B.X., Hillmer, S., Zhao,M., Lo, S.W., Robinson, D.G., and *Jiang, L (2004) Identification of multivescular bodies as prevacuolar compartments in Nicotiana tabacum BY-2 cells. The Plant Cell 16: 672-693.
14. Jin, J.B., Bae,H., Kim, S.J., Go, C., Kim,D.H., Lee, Y.J., Tse, Y.C., Jiang, L and Hwang, I. (2003) Arabidopsis dynamin-like proteins, ADL1C and ADL1E, play a critical role in mitochondrial morphogenesis. The Plant Cell 15: 2357-2369.
15. Mo, B.X., Tse, Y.C. and *Jiang, L. (2003) Organelle identification and proteomics in plant cells. Trends in Biotechnology 21: 331-332.
16. Sohn, E.S., Kim, E.S., Zhao, M., Kim, S.J., Kim, H.R., Kim, Y.W., Lee, Y.J., Hillmer, S., Sohn, U., Jiang, L., and Hwang, I. (2003) Rha1, an Arabidopsis Rab5 homolog, plays a critical role in the vacuolar trafficking of soluble cargo proteins. The Plant Cell 15:1057-1070.
17. *Jiang, L. and Rogers, J.C. (2003) Sorting of lytic enzymes in the plant Golgi apparatus. Annual Plant Review 9: 114-140.
18. Jiang, L., Erickson, A. and Rogers, J.C. (2002) Multivesicular bodies: a mechanism to package lytic and storage function in one organelle? Trends in Cell Biology 12: 362-367.
19. Li, Y.B., Rogers, S.W., Tse, Y.C., Lo, S.W., Sun, S.S.M., Jauh, G.Y. and *Jiang, L. (2002) BP-80 and homologs are concentrated on post-Golgi, probable lytic prevacuolar compartments. Plant & Cell Physiology 43: 726-742.
20. *Jiang, L. and Sun, S.S.M. (2002) Membrane anchors for vacuolar targeting: application in plant bioreactors. Trends in Biotechnology 20: 99-102. (cover article)
21. Jiang, L., Phillips, T.E., Hamm, C.A., Drozdowicz, Y.M., Rea, P.A., Maeshima, M., Rogers, S.W. and Rogers, J.C. (2001) The protein storage vacuole: a unique compound organelle. The Journal of Cell Biology 155: 991-1002. (journal highlight article)
22. Jiang, L., Phillips, T.E., Rogers, S.W. and Rogers, J.C. (2000) Biogenesis of the protein storage vacuole crystalloid. The Journal of Cell Biology 150: 755-769.
23. Jiang, L. and Rogers, J.C. (1999) Functional analysis of a Golgi-localized Kex2p-like protease in tobacco suspension culture cells. The Plant Journal 18: 23-32.
24. Jiang, L. and Rogers, J.C. (1998) Integral membrane protein sorting to vacuoles in plant cells: evidence for two pathways. The Journal of Cell Biology 143: 1183-1199. (this article was featured in Trends in Cell Biology)

 

Research Grants

Research Grants Council (RGC) Earmarked Grants
2008-2010 Molecular characterization of plant endocytosis - HK$1,408,404 (as PI)
2006-2008 The biology of vacuolar sorting receptor proteins and their applications in plant bioreactors - HK$1,446,465 (as Co-PI, PI, Prof. SSM Sun)
2003-2008 Biogenesis of the compound protein storage vacuole - HK$2,394,000 (as PI)
2002-2005 Molecular characterization of plant prevacuolar compartments - HK$1,387,580 (as PI)
2001-2004 Sorting of proteins to the protein storgae vacuole in plant cells - HK$1,154,000 (as PI, Co-I, Prof SSM Sun)
   
CUHK Scheme C
2006-2009 Molecular characterization of plant prevacuolar compartments - HK$1,086,000 (as PI)
   
National Nature Science Foundation of China (NSFC)
2006-2008 Biogenesis of protein storage vacuole and its application - RMB$400,000 (as PI; collaborator, Prof. ZF Xu)
 
The National High Technology Research and Development Program of China (863 Program)
2008-2010 Plant cells as bioreactors for pharmaceuticals - RMB$1,000,000 (50% of the fund as Co-I; PI, Prof. ZF Xu)
   
France / Hong Kong Joint Research Scheme
2003-2004 Molecular mechanism of plant prevacuolar compartments - HK$63,000
   
Gemany / Hong Kong Joint Research Scheme
2002-2003 Protein sorting in the plant Golgi - HK$60,000
2007-2008 Structural characterization and proteomics of plant prevacuolar compartments - HK$60,000

 

Awards
2009-10 The Prestigious Senior Research Fellowship of The Croucher Foundation
2008 Exemplary Teaching Award, Faculty of Science, The Chinese University of Hong Kong

 

 

 

 

 

 

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