Position

Research Interests

1. Application of NMR Spectroscopy and Density Functional Theoretical Method to the study of chemical shift and structure relationship in biomolecules.
2. Synthesis of transition metal complexes with pharmaceutical implications.

Representative Publications

1. X.P. Xu, W.L.A.K. Chiu and Steve C.F. Au-Yeung, 
   "Chemical shift and Structure Relatioship in Nuclei Acid-Correlation of Backbone Torsion Angles γ and α with ¹³C Chemical Shift" 
   J. Amer. Chem. Soc., 120, 4230-4231 (1998).
2. Xiao-Ping Xu and Steve C.F. Au-Yeung, 
   "Investigation of Chemical Shift and Structure Relationship in Nuclei Acid using NMR and Density Functional methods" 
   J. Phys. Chem. , B, 104 (23), 5641-5650 (2000).
3. Xiao-Ping Xu and Steve C.F. Au-Yeung, 
   "A DFT and Co-59 Solid-State NMR Study of the Chemical Shielding property and electronic interaction in the metalloporphyrin system" 
   J. Amer. Chem. Soc., 122 (27), 6468-6475 (2000).
4. W.L.A.K. Chiu, C.N. Sze; L.N. IP; S.K. Chan and Steve C.F. Au-Yeung, 
   "NTDB: Thermodynamics Database for Nucleic Acids" 
   Nucleic Acids Research, 29 (1), 230-233 (2001).
5. Yee-Ping Ho, Kenneth K.W. To, Steve C.F. Au-Yeung, Xinning Wang, Ge Lin, and Xiuwen Han, 
   "Potential New Antitumor Agents from an Innovative combination of Demethylcantharidin, a Modified Traditional Chinese Medicine, with a Ptatinum Moiety" 
   J. Med. Chem., 44(13), 2065-2068 (2001).
6. Wing Lok A.K. Chiu, Chun Ngai Sze, Steve C.F. Au-Yeung* and XiuWeng Han 
   "Thermodynamic studies in nucleic acids: a summary of recent work" 
   Current Topics in Analytical Chemistry, 2, 95 -120 (2001).
7. Kenneth K.W. To, Yee Ping Ho and Steve C.F. Au-Yeung 
   "Determination of the release of hydrolyzed demethylcantharidin from novel traditional chinese medicine-platinum compounds with anticancer activity by gas chromatorgraphy" 
   J. Chrom. A, 947, 319-326 (2002)
8. Yee Ping Ho, Steve C.F. Au-Yeung and Kenneth K.W. To 
   Platinum-Based Anticancer Agents: Innovative Design Strategies and Biological Perspectives" 
   Medicinal Research Review, 23(5), 633-655 (2003).
9. Wing Lok Abe Kurtz Chiu, Chun Ngai Sze, Nap Tak Ma, Lai Fan Chiu, Chung Wai Leung and Steve C.F. Au-Yeung 
   "NTDB: Thermodynamic Database for Nucleic Acids, Version 2.0" 
   Nucleic Acids Research, 31(1), 483-485 (2003).
10. Yibing Gao, Steve C.F. Au-Yeung, Suhong Kazuya Yamamoto, Mitsuru Akashi and Chi Wu 
    "Interaction of water with Protein-like Poly(N-isopropylacrylamide) and Poly(N-vinylisobutyramide) during the Coil-to-Globule Transition - A NMR and DFT Mechanistic Study" 
    J. Amer. Chem. Soc., submitted.
11. Kenneth K.W. To, Yee Ping Ho and Steve C.F. Au-Yeung
    "Circumvention of Cisplatin Resistance by Novel Traditional Chinese Medicine-Platinum Anticancer Agents" 
    International Journal of Cancer, submitted.
12. Kenneth K.W. To, Yee Ping Ho and Steve C.F. Au-Yeung 
    "In-vitro and in-vivo suppression of growth of hepatocellular carcinoma cells by novel traditional chinese medicine-platinum anticancer agents" 
    Cancer Letters, submitted.
13. Siu-Kwong Pang and Steve C.F. Au-Yeung 
    "DFT Study of the reaction pathways in cis-platin guanine binding"
    to be submitted.
14. Siu-Kwong Pang and Steve C.F. Au-Yeung 
    "Chemical Hardness - a unique quantitative indicator of structure-activity relationship in metal-based drugs " 
    to be submitted.

Patent

United States Patent: 
Steve C.F. Au-Yeung, Yee Ping Ho, Lin Ge, Han Xiuwen, Wang Xinning, Lu Shiwei & Jiang Tao, "Synthesis of Platinum Complexes and Uses Thereof" 
USP 6110907, August 2000.

Professional Activities

1. Member of the American Association for the Advancement of Science.
2. Member of the Chinese Magnetic Resonance Society.
3. Member of the International Society of Magnetic Resonance.
4. Member of the Editorial Board, Chinese Journal of Magnetic Resonance since 1992.