Department of Chemical Pathology, The Chinese University of Hong Kong

Professor Dennis Lo

Professor Rossa Chiu

Professor Allen K C Chan

Professor Nelson Tang

Professor Chun Kwok Wong

Professor Kathy Lui

Professor Sung Wing Kin

Professor Peiyong Jiang

Professor Peter Cheung

Professor Hei Ming Lai

Professor Jacky Lam

Professor Guanhua Zhu

Professor Chun Kit Choi

Professor Mingyuan Li

Professor Qing Zhou

Professor Nirmal Panesar

Professor Chung Shun Ho

Dr Michael H M Chan

Dr Jeffrey SS Kwok

Kathy Lui 呂愛蘭
Professor 教授
Research Grants Council Research Fellow

kathyolui@cuhk.edu.hk

Biography

Dr. Kathy Lui obtained her Bachelor of Science and Master of Philosophy degrees from the Department of Biochemistry, The Chinese University of Hong Kong. Supported by the full scholarship Dorothy Hodgkin Postgraduate Award, Dr. Lui completed her Ph.D at Sir William Dunn School of Pathology, University of Oxford, U.K. focusing on stem cell immunology under the supervision of Prof. Herman Waldmann. She was honored with the Senior Scholarship at Lincoln College, Oxford, and the Peter Beaconsfield Prize in Physiological Sciences. Thereafter, Dr. Lui was awarded the Croucher Foundation Fellowship and pursued her postdoctoral training at Massachusetts General Hospital, where she investigated cardiovascular regeneration in Prof. Kenneth Chien’s lab, and at the Department of Stem Cell and Regenerative Biology, Harvard University, U.S., focusing on stem cell and regeneration in Prof. Douglas Melton’s lab.

In August 2014, Dr. Lui has established her own research group, studying disease mechanisms and therapeutic strategies targeting cardiovascular repair using stem cells as a primary modelling tool. More recently, she focused to study the contributions of immune cells particularly different T cell subsets to cardiovascular disease and repair. Her contributions have been recognized with the Croucher Innovation Award in 2017. She was among the first recipients of China’s NSFC Excellent Young Scientists Fund in 2019, and was honored with the title of RGC Research Fellow in 2022. She is also a founding member of the Young Academy of Sciences of Hong Kong in 2018, and continues to play an active role in the Academy for promoting science education in Hong Kong.

The following highlights her current research efforts:

•	Cardiovascular Immunology
•	Cardiovascular Repair and Regeneration
•	Molecular mechanisms driving cardiovascular disease progression

Other official website:

https://www.lihs.cuhk.edu.hk/en-us/research/investigators/luikathy.aspx

Personal lab website:

http://www.cuhk.edu.hk/research/luilab

*Selected Publications ( Correspondence):**
1.	Lui KO, Ma Z, Dimmeler S. SARS-CoV-2 induced vascular endothelial dysfunction: direct or indirect effects? Cardiovascular Research 120:34-43
2.	Han M, Liu Z, Liu L, Huang X, Wang H, Pu W, Wang E, Liu X, Li Y, He L, Li X, Wu J, Qiu L, Shen R, Wang Q, Ji Y, Ardehali R, Shu Q, Lui KO, Wang L, Zhou B. (2023) Dual genetic tracing reveals a unique fibroblast subpopulation modulating cardiac fibrosis. Nature Genetics*. 55:665-678\
3.	Han M, Liu Z, He L, Li X, Liu L, Huang X, Zhang M, Yan Y, Lui KO, Zhou B. (2022) Dual genetic lineage tracing reveals capillary to artery formation in the adult heart. Circulation* 145:1179-1181
4.	Liu D, Yang KY, Chan VW, Ye W, Chong CCN, Wang CC, Wang H, Zhou B, Cheng KKY, Lui KO. (2022) YY1 regulates glucose homeostasis through controlling insulin transcription in pancreatic beta cells. Diabetes*. 71:961-977.
5.	Ma Z, Li X, Fan RLY, Yang KY, Ng CSH, Lau RWH, Wong RHL, Ng KK, Wang CC, Ye P, Fu Z, Chin AWH, Lai MYA, Huang Y, Tian XY, Poon LLM, Lui KO*. (2022) A human pluripotent stem cell-based model of SARS-CoV-2 infection reveals an ACE2-independent inflammatory activation of vascular endothelial cells through TLR4. Stem Cell Reports*. 17:538-555.
6.	Zhang S, Li Y, Huang X, Liu K, Wang QD, Chen AF, Sun K, Lui KO*, Zhou B. (2021) Seamless genetic recording of transiently activated mesenchymal gene expression in endothelial cells during cardiac fibrosis. Circulation. 144:2004-2020.
7.	Li X, Yang KY, Chan VW, Leung KT, Zhang XB, Wong AS, Chong CCN, Wang CC, Ku M, Lui KO. (2020) Single cell RNA-Seq reveals that CD9 is a negative marker of glucose-responsive pancreatic beta-like cells derived from human pluripotent stem cells. Stem Cell Reports* 15:1111-1126.
8.	Li J, Liang C, Yang KY, Huang X, Han MY, Li X, Chan VW, Chan KS, Liu D, Huang ZP, Zhou B, Lui KO*. (2020) Specific ablation of CD4+ T-cells promotes heart regeneration in juvenile mice. Theranostics* 10: 8018-8035.
9.	Li J, Li X, Liang C, Ling J, Chen Z, Wong CK, Waldmann H, Lui KO. (2020) Coreceptor blockade targeting CD4 and CD8 allows acceptance of allogeneic human pluripotent stem cell grafts in humanized mice. Biomaterials*. 248: 120013.
10.	Liang C, Yang KY, Chan VW, Li X, Fung THW, Wu Y, Tian XY, Huang Y, Qin L, Lau JYW, Lui KO. (2020) CD8+ T-cell plasticity regulates vascular regeneration in type-2 diabetes. Theranostics* 10: 4217-4232.
11.	Li J, Yang KY, Tam RCY, Chan VW, Lan HY, Hori S, Zhou B, Lui KO. (2019) Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner. Theranostics*. 9: 4324-4341.
12.	Leung CS, Li J, Xu F, Wong ASL, Lui KO. (2019) Ectopic expression of recipient CD47 inhibits mouse macrophage-mediated immune rejection against human stem cell transplants. FASEB J*. 33: 484-493.
13.	Leung CS, Yang KY, Li X, Chan VW, Ku M, Waldmann H, Hori S, Tsang JCH, Lo YMD, Lui KO. (2018) Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T-cells. Genome Medicine*. 10: 71.
14.	Leung OM, Li J, Li X, Chan VW, Yang KY, Ku M, Ji L, Sun H, Waldmann H, Tian XY, Huang Y, Lau J, Zhou B, Lui KO. (2018) Regulatory T cells promote apelin mediated sprouting angiogenesis in type 2 diabetes. Cell Reports*. 24: 1610-1626.
15.	Lui KO, Howie D, Ng SW, Liu SB, Chien KR, Waldmann H. (2014) Tolerance induction to human stem cell transplants with extension to their differentiated progeny. Nature Communications. 5: 5629.
16.	Zangi L#, Lui KO#, von Gise A, Ma Q, Ebina W, Ptaszek LM, Spater D, Xu HS, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, Rossi DJ, Pu WT, Chien KR. (2013) Modified mrna directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nature Biotechnology. 31: 898-907. #Equal contribution
17.	Lui KO, Zangi L, Silva EA, Bu L, Sahara M, Li RA, Mooney DJ, Chien KR. (2013) Driving vascular endothelial cell fate of human multipotent isl1(+) heart progenitors with VEGF modified mRNA. Cell Research. 23: 1172-1186.
18.	Lui KO, Boyd AS, Cobbold SP, Waldmann H, Fairchild PJ. (2010) A role for regulatory t cells in acceptance of esc-derived tissues transplanted across an major histocompatibility complex barrier. Stem Cells. 28: 1905-1914.