The mission of our research programs is to elucidate cellular and molecular events involved in the initiation and progression of endothelial dysfunction in hypertension, diabetes and atherosclerosis, to uncover novel relevant biomarkers for vascular dysfunction, and develop venues to reverse vascular function and aging in animal models of cardio-metabolic diseases including hypertension, diabetes, dyslipidemia, atherosclerosis, renal dysfunction, as well as to train top-quality research students. Our main research focuses on endothelial dysfunction and functional communication between endothelium and other organs such as adipose tissue and bone. The program is continuously funded by grants from the Hong Kong Research Grants Council, Hong Kong Food and Health Bureau, and Natural Science Foundation of China. Our research platform affiliated with the Department of Biomedical Sciences, City University of Hong Kong has provided ample opportunities for closer collaborations with endocrinologists, clinical pharmacologists, and basic scientists in Hong Kong and around the world aiming at deeper understanding of pathophysiological mechanisms and exploring new therapeutic strategies against cardiovascular and metabolic diseases.

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