Prof LEUNG Kai Shun Christopher 梁啟信教授
MB ChB (CUHK), MD (CUHK), BMedSc, MSc (Lond), FCOphth (HK), FHKAM (Ophth)

Professor
Head, Graduate Division of OVS
Office tel.: (852) 3943-5846
Fax no.: (852) 2715-9490
e-mail: cksleung@cuhk.edu.hk
（中文版）

Biography

Prof Christopher Leung is Professor of Department of Ophthalmology & Visual Sciences at the Chinese University of Hong Kong (CUHK). He is a clinician-scientist with research focus on glaucoma management and investigation. He received the Degree of Doctor of Medicine (MD, CUHK) 5 years after completing his undergraduate medical training in Hong Kong (MB ChB, CUHK). He was then awarded the Croucher Foundation Fellowship and completed a clinical and research fellowship in glaucoma at the Hamilton Glaucoma Center, the University of California, San Diego (UCSD). Awarded with the Chevening Postgraduate Scholarship, Prof Leung also received postgraduate training in molecular medicine at the Imperial College London.

Prof Leung is Section Editor of British Journal of Ophthalmology and Asia Pacific Journal of Ophthalmology, Contributing Editor of International Glaucoma Review, Editorial Board Member of Ophthalmic Epidemiology, Recent Patents on Medical Imaging, and Ocular Surgery News (Asia Pacific Edition), Associate Advisory Board Member of the World Glaucoma Association, and reviewer of over 30 peer-reviewed scientific journals. He has been senior instructor and invited speaker in various academic conferences including the annual meetings of American Academy of Ophthalmology, Association for Research in Vision and Ophthalmology, Asia Association for Research in Vision and Ophthalmology, Asia Pacific Academy of Ophthalmology, World Glaucoma Congress, World Ophthalmology Congress, World Ophthalmology Leaders Forum in Education, and the Glaucoma Foundation Think Tank Meeting.

Prof Leung has received a number of local and international research and service awards including the Hong Kong Medical Association Prize (1996), Action for Vision Eye Foundation Young Researcher (2004), Outstanding Researcher (2005), and Best Researcher (2008-2009) Awards, National Best Paper on Prevention of Blindness in the World Ophthalmology Congress (2006), UCSD Schanzlin Research Award (2007), the American Academy of Ophthalmology Achievement Award (2008), the Asia Pacific Academy of Ophthalmology Nakajima Award (2010), Asia Pacific Academy of Ophthalmology Achievement Award (2010), the Association for Research in Vision and Ophthalmology Alcon Clinician-Scientist Research Award (2010), the Asia Pacific Joint Glaucoma Congress Young Scientist Award (2010), World Glaucoma Congress Clinician Scientist Award (2011), Asia-Pacific Glaucoma Society Young Investigator Award (2012), the American Academy of Ophthalmology Secretariat Award (2012), and the Asia Pacific Academy of Ophthalmology Distinguished Service Award (2014).

In collaboration with Prof Robert N. Weinreb, Director of Hamilton Glaucoma Center at UCSD, Prof Leung developed a new experimental model for imaging individual retinal ganglion cells in vivo, which bestowed him with the World Glaucoma Association (WGA) Science Award - the Promise in 2009. This model provides a non-invasive and efficient approach to serially monitor the integrity of retinal ganglion cells and has facilitated the investigation of retinal ganglion cell degeneration and neuroprotection in glaucoma. With funding support provided by the Glaucoma Foundation (New York, NY), the American Health Assistance Association (Clarksburg, MD), and General Research Fund (Hong Kong), Prof Leung is currently investigating the cellular and molecular mechanisms for promoting retinal ganglion cell survival in glaucoma and optic neuropathies. He is also principle investigator of a number of clinical and translational research projects studying the application of advanced imaging technologies for early detection and monitoring of glaucoma, surgical and laser procedures for lowering intraocular pressure, and therapies to protect and regenerate retinal ganglion cells in glaucoma and other forms of optic neuropathies.

Selected publications

Textbooks

  • Weinreb RN, Garway-Heath D, Leung CK, Medeiros FA, Crowston JG. ed. Consensus Series 8 – Progression of Glaucoma. Hague, Netherlands: Kugler Publications, 2011.10.
  • Leung CK, Lam DS, Wang N, Ritch R, Weinreb RN. ed. Glaucoma Diagnostics. Series Name: A-Z in Ophthalmology. Bon Vision Limited, Hong Kong. 2008.07.

Book Chapters

  • Leung CK, Chan CK. Approach to the diagnosis and differentiation of glaucomatous and nonglaucomatous optic neuropathies. Optic Nerve Disorders - Diagnosis and Management 2nd Edition. ed. by. Jane W. Chan. p.281-308. Springer 2014.
  • Leung CK. Primary acute angle closure and chronic angle closure glaucoma. Color Atlas & Synopsis of Clinical Ophthalmology, Wills Eye Hospital, Glaucoma. ed. by Rhee DJ. 2nd ed. p.270-281. United States of America: Lippincott Williams & Wilkins, 2012.
  • Leung CK. Laser Peripheral Iridotomy. SLACK Incorported ed. by Malik Y. Kahook. p.203-206. United States of America, 2012.
  • Leung CK. Unmet needs. Consensus Series 7 – Medical Treatment of Glaucoma. ed. by Weinreb RN and Liebmann J. The Hague, The Netherlands: Kugler; 2010.

Peer-reviewed Journal Articles

  • Clinical studies
    • Xu G, Weinreb RN, Leung CK. Optic nerve head deformation in glaucoma: The temporal relationship between optic nerve head surface depression and retinal nerve fiber layer thinning. Ophthalmology. 2014;121:2362-70.
    • Leung CK, Ye C, Weinreb RN, Yu M, Lai G, Lam DS. Impact of age-related change of retinal nerve fiber layer and macular thicknesses on evaluation of glaucoma progression. Ophthalmology. 2013;120:2485-92.
    • Mak H, Xu G, Leung CK. Imaging the iris with swept-source optical coherence tomography: relationship between iris volume and primary angle closure. Ophthalmology. 2013;120:2517-24.
    • Leung CK, Yu M, Weinreb RN, Lai G, Xu G, Lam DS. Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: Patterns of retinal nerve fiber layer progression. Ophthalmology. 2012;119:1858-66.
    • Leung CK, Liu S, Weinreb RN, Lai G, Ye C, Cheung CY, Pang CP, Tse KK, Lam DS. Evaluation of retinal nerve fiber layer progression in glaucoma: A prospective analysis with neuroretinal rim and visual field progression. Ophthalmology. 2011;118:1551-7
    • Leung CK, Choi N, Weinreb RN, Liu S, Ye C, Lai G, Lau J, Lam DS. Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography – pattern of RNFL defects in glaucoma. Ophthalmology. 2010;117:2337-44.
    • Leung CK, Lam S, Weinreb RN, Liu S, Ye C, Liu N, He J, Lai G, Li T, Lam DS. Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography – analysis of the RNFL map for glaucoma detection. Ophthalmology. 2010; 117:1684-91.
    • Narayanaswamy A, Leung CK, Istiantoro DV, Perera SA, Ho CL, Nongpiur ME, Baskaran M, Htoon HM, Wong TT, Goh D, Su DH, Belkin M, Aung T. Efficacy of selective laser trabeculoplasty in primary angle-closure glaucoma: A randomized clinical trial. JAMA Ophthalmol. 2014.
  • Experimental studies
    • Liu S, Li ZW, Weinreb RN, Xu G, Lindsey JD, Ye C, Yung WH, Pang CP, Lam DS, Leung CK. Tracking retinal microglia density in models of retinal ganglion cell damage. Invest Ophthalmol Vis Sci. 2012;53:6254-62.
    • Li ZW, Liu S, Weinreb RN, Lindsey JD, Yu M, Liu L, Ye C, Cui Q, Yung WH, Pang CP, Lam DS, Leung CK. Tracking dendritic shrinkage of retinal ganglion cells after acute elevation of intraocular pressure Invest Ophthalmol Vis Sci. 2011;52:7205-12.
    • Leung CK, Weinreb RN, Li ZW, Liu S, Lindsey JD, Choi N, Liu L, Cheung CY, Ye C, Qui K, Chen LJ, Yung WH, Crowston JG, Pu M, So KF, Pang CP, Lam DS. Long‐term In vivo Imaging and Measurement of Dendritic Shrinkage of Retinal Ganglion Cells. Invest Ophthalmol Vis Sci. 2011;52:1539-47.
    • Leung CK, Weinreb RN. Experimental detection of retinal ganglion cell damage in vivo. Exp Eye Res. 2009;88:831-6.
    • Leung CK, Lindsey JD, Chen L, Liu Q, Weinreb RN. Longitudinal profile of retinal ganglion cell damage assessed with blue-light confocal scanning laser ophthalmoscopy after ischemic reperfusion injury. Br J Ophthalmol. 2009;93:964-8.
    • Leung CK, Lindsey JD, Crowstan JN, Chen LJ, Weinreb RN. Longitudinal Profile of Retinal Ganglion Cell Degeneration After Optic Nerve Crush – A Blue-Light Confocal Scanning Laser Ophthalmoscope Imaging Study. Invest Ophthalmol Vis Sci. 2008;49:4898-902.
    • Leung CK, Lindsey JD, Crowston JA, Ju WK, Liu Q, Bartsch DU, Weinreb RN. In vivo imaging of murine retinal ganglion cells. Journal of Neuroscience Methods. 2008;168:475-8.
Academic Faculty