Dr Fung Ping Leung, Chirstina

Postdoctoral Research Fellow (2003-2009) Department of Physiology, Chinese University of Hong Kong, Hong Kong

Postdoctoral Research Fellow (2009-2011) University of Hong Kong

Current the Research Assistant Professor School of Chinese Medicine at Hong Kong Baptist University, Hong Kong

• Leung FP, Yung LM, Ngai CY, Cheang WS, Tian XY, Lau CW, Zhang Y, Liu J, Chen ZY, Bian ZX, Yao X & Huang Y (2016) Chronic black tea consumption improves endothelial function in ovariectomized rats. European Journal of Nutrition 55(5):1963-1972.

• Cheang WS, Ngai CY, Tam YY,  Tian XY, Wong WT, Zhang Y, Lau CW, Chen ZY, Bian ZX, Huang Y & Leung FP (2015) Black tea protects against hypertension-associated endothelial dysfunction through alleviation of endoplasmic reticulum stress. Scientific Reports 5:10340

• Zhang M, Zang KH, Luo JL, Leung FP, Huang Y, Lin CY, Yang ZJ, Lu AP, Tang XD, Xu HX, Sung JJ, Bian ZX (2013). Magnolol inhibits colonic motility through down-regulation of voltage-sensitive L-type Ca2+ channels of colonic smooth muscle cells in rats. Phytomedicine 20(14):1272-1279

• YUNG LM, Tian XY, Wong WT, Leung FP, Yung LH, Chen ZY, Lau CW, Yao YX & Huang Y (2013) Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats. European Journal of Nutrition 52(3):1145-1155.

• Tian XY, Yung LH, Wong WT, Leung FP, Liu LM, Chen YC, Kong SK, Kwan KM, Ng SM, Lai PB, Yung LM, Yao X & Huang Y (2012) Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway. Journal of Molecular and Cellular Cardiology 52(1):237-244.

• CHAN YC, LEUNG FP, TIAN XY, YUNG LM, LAU CW, CHEN ZY, YAO X, LAHER I, HUANG Y. (2012) Raloxifene improves vascular reactivity in pressurized septal coronary arteries of ovariectomized hamsters fed cholesterol diet. Pharmacological Research 65(20):182-188.

• Tian XY, Wong WT, Leung FP, Zhang Y, Wang YX, Lee HK, Ng CF, Chen ZY, Yao X, Au CL, Lau CW, Vanhoutte PM, Cooke JP & Huang Y (2012) Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin F2a impairs endothelial function in renovascular hypertensive rats Antioxidants & Redox Signaling 16(4):363-373.

• Wong CK, So WY, Law SK, Leung FP, Yao X, Huang Y, Li X & Tsang SY (2012) Estrogen controls the proliferative characteristic of embryonic stem cells via store-operated calcium entry and the transcription factor nuclear factor of activated T-cells (NFAT). Journal of Cellular Physiology 227(6):2519-2530.

• YUNG LM, WONG WT, TIAN XY, LEUNG FP, YUNG LH, Chen ZY, Yao X, Lau CW, Huang Y (2011). Inhibition of renin-angiotensin system reverses endothelial dysfunction and oxidative stress in estrogen deficient rats. PLoS One. 29;6(3):e17437.

• Wong WT, Tian XY, Chen YC, Leung FP, Liu L, Lee HK, Ng CF, Xu A, Yao X, Vanhoutte PM, Tipoe GL & Huang Y (2010) Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: Implications on hypertension. Circulation Research 107(5):984-991.

• Yip KH, Huang Y, Leung FP, & Lau HYA (2010). Cyclic guanosine monophosphate dependent pathway contributes to human mast cell inhibitory actions of the nitric oxide donor, diethylamine NONOate. European Journal of Pharmacology. 632(1-3):86-92.

• Zhang Man, Leung FP, Huang Y & Bian ZX (2010). Up-regulation of L-type calcium channel mediates increased contractility of colonic smooth muscle in a rat model of irritable bowel syndrome. Neurogastroenterology & Motility. 22(5):e162-e170

• Chan YC, Leung FP, Wong WT, Yung LM, Tian TY, Tsang SY, Yao Y, Chen ZY, Huang Y (2010). Therapeutically Relevant Concentrations of Raloxifene Dilate Pressurized Rat Resistance Arteries via Calcium-dependent eNOS Activation. Arteriosclerosis, Thrombosis and Vascular Biology 30(5):992-999 (Co-first author)

• Liu CQ, Wong SL, Leung FP, Tian XY, Lau CW, Lu LM, Yao X, Chen ZY, Yao T & Huang Y (2010). Prostanoid TP receptor-mediated impairment of cyclic AMP-dependent vasorelaxation is reversed by phosphodiesterase inhibitors. European Journal of Pharmacology. 632(1):45-51.

• LEUNG FP, MILLER AL, KORZH V, CHONG SW, SLEPTOSOVA-FREIDRICH I, WEBB SE.(2009).Visualization of stochastic Ca2+ signals in the formed somites during the early segmentation period in intact, normally developing zebrafish embryos. Development, Growth and Differentiation. 51(7):617-37.

• Kwan HY, Huang Y, Yao XQ, Leung FP. (2009) Role of cyclic nucleotides in the control of cytosolic Ca2+ levels in vascular endothelial cells. Clin Exp Pharmacol Physiol. 36(9):857-66.

• Liu CQ, Leung FP, Wong SL, Wong WT, Lau CW, Lu L, Yao X, Yao T, Huang Y. (2009) Thromboxane prostanoid receptor activation impairs endothelial nitric oxide-dependent vasorelaxations: the role of Rho kinase. Biochem Pharmacol. 78(4):374-81.

• Yip KH, Leung FP, Huang Y, & LAU HYA (2009) Inhibition of anti-IgE mediated human mast cell activation by NO donors is dependent on the NO release kinetics of the donors. Br J Pharmacol. 156(8):1279-1286.

• LEUNG KW, LEUNG FP, MAK NK, JOYCE TOMBRAN-TINK, HUANG Y & WONG RNS (2009). Protopanaxadiol and protopanaxatriol bind to glucocorticoid and estrogen receptors in endothelial cells. British Journal of Pharmacology 156(4):626-37. (Co-first author)

• HERCULE HC, SCHNUCK W, GROSS V, SERINGER J, LEUNG FP, WELDON SM, DA COSTA GONCALVES AC, HUANG Y, LUFT FC & GOLLASCH M (2009) Interaction between P450 eicosanoids and nitric oxide in the control of arterial tone in mice. Arteriosclerosis, Thrombosis and Vascular Biology. 29(1):54-60.

• WONG SL, LEUNG FP, C LAU, YUNG LM, LAU CW, YAO X, CHEN ZY, VANHOUTTE PM & HUANG Y (2009) Essential role of cyclooxygenase-2 in endothelium-dependent contraction and the generation of EDCF(s). Circulation Research. 104(2):228-35.

• WONG CM, YUNG LM, LEUNG FP, TSANG SY, AU CL, YAO X, CHENG HK, CHEN ZY & HUANG Y (2008). Raloxifene protects endothelial cells against oxidative stress. British Journal of Pharmacology. 155(3):326-34.

• YUNG LM, LEUNG FP, WONG WT, TIAN XY, YUNG LH, CHEN ZY, YAO XQ & HUANG Y (2008) Tea polyphenols benefit vascular function. Inflammopharmacology. 16(5):230-4.

• LEUNG FP, YUNG LM, LAHER I, YAO X, CHEN ZY & HUANG Y (2008). Exercise, vascular wall and cardiovascular health – Part 1. Sports Medicine. 38(12):1009-24.

• YUNG LM, HUANG Y, LAHER I, YAO X, CHEN ZY & LEUNG FP (2009). Exercise, vascular wall and cardiovascular health – Part 2. Sports Medicine. 39(1):45-63. (Corresponding author)

• LIU CQ, LEUNG FP, LEE WY, LAU CW, YAO XQ, LU LM, HUANG Y (2008). Prevention of nitroglycerin tolerance in vitro by T0156, a selective phosphodiesterase type 5 inhibitor. European Journal of Pharmacology. 590:250-254.

• Leung FP, YUNG LM, YAO X, LAHER I & HUANG Y (2008). Stored-operated calcium entry in vascular smooth muscle. British Journal of Pharmacology. 153(5):846-57.

• CHAN YC, LEUNG FP, YAO X, LAU CW, VANHOUTTE PM, HUANG Y (2007). Raloxifene modulates pulmonary vascular reactivity in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 49(6):355-61.

• ZHONG JC, HUANG Y, YUNG LM, LAU CW, Leung FP, WONG WT & YU XY (2007). The novel peptide apelin regulates intrarenal artery tone in diabetic mice. Regulatory Peptides. 144(1-3):109-14.

• LEUNG FP, YUNG LM, LEUNG HS, Au CL, YAO X, VANHOUTTE PM, LAHER I & HUANG Y (2007). Therapeutic concentrations of raloxifene augments nitric oxide dependent relaxation in porcine coronary artery. British Journal of Pharmacology. 152(2):223-229.

• LEUNG FP, TSANG SY, YUNG LM, WONG CM, CHAN YC, LEUNG HS, YAO X & Huang Y (2007). Raloxifene, tamoxifen and vascular tone. Clinical and Experimental Pharmacology and Physiology (invited article to A Special Issue on Steroid Hormones and Vascular Function). 34(8):809-813.

• WONG SL, YUNG LM, LAU CW, WONG WT, CHAN YC, HUANG Y & LEUNG FP (2007). Impact of periadventitial adipose tissue on arterial tone. Journal of Internal Medicine Concept and Practice. 3(2):139-141. (Corresponding author)

• TANG EH, LEUNG FP, HUANG Y, FELETOU M, SO KF, MAN RY & VANHOUTTE PM (2007). Calcium and reactive oxygen species increase in endothelial cells in response to releasers of endothelium-derived contracting factor. British Journal of Pharmacology. 151(1):15-23.

• LEUNG KW, LEUNG FP, HUANG Y, MAK NK & WONG RN (2007). Non-genomic effects of ginsenoside – Re in endothelial cells via glucocorticoid receptor. FEBS Letters. 581(13):2433-2438.

• LEUNG HS, SETO SW, KWAN YY, LEUNG FP, AU ALS, YUNG LM, YAO X & HUANG Y (2007). Endothelium-independent relaxation to raloxifene in porcine coronary artery. European Journal of Pharmacology. 555(2-3):178-184.

• LEUNG HS, YUNG LM, LEUNG FP, YAO X, CHEN ZY, KO WH, LAHER I & HUANG Y (2006). Tamoxifen dilates porcine coronary arteries: role of nitric oxide and ouabain sensitive mechanisms. British Journal of Pharmacology. 149(6): 703-711.

• YUNG LM, LEUNG FP, YAO X, CHEN ZY & HUANG Y (2006). Reactive Oxygen Species in Vascular Wall. Cardiovascular & Haematological Disorders - Drug Targets. 6(1):1-19.

• LEUNG HS, LEUNG FP, YAO X, KO WH, CHEN ZY, VANHOUTTE PM & HUANG Y (2006). Endothelial mediators of the acetylcholine-induced relaxation of the rat femoral artery. Vascular Pharmacology. 44(5):299-308.

• LEUNG HS, YAO X, LEUNG FP, KO WH, CHEN ZY, GOLLASCH M & HUANG Y (2006). Cilnidipine, a slow-acting Ca2+ channel blocker, induces relaxation in porcine coronary artery: role of endothelial nitric oxide and [Ca2+]i. British Journal of Pharmacology. 147(1):55-63.

• CHAN YC, LEUNG FP, YAO X, LAU CW, VANHOUTTE PM & HUANG Y (2005). Raloxifene relaxes rat pulmonary arteries and veins: Roles of gender, endothelium and antagonism of Ca2+ influx. Journal of Pharmacology and Experimental Therapeutics. 312:1266-71.

• LEUNG FP, YAO X, LAU CW, LU L & HUANG Y (2005). Raloxifene relaxes rat intrarenal arteries through inhibition of Ca2+ influx via L-type Ca2+ channel. American Journal of Physiology - Renal Physiology. 289:F137-44.