CUHK Huang Yu
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Prof. Xiaoyu TIAN

 
SCI-indexed publications

  • Cheng CK, Lin X, Pu Y, Tse KYJ, Wang Y, Zhang CL, Cao X, Lau CW, Huang J, He L, Luo JY, Shih YT, Wan S, Ng CF, Wang L, Ma CWR, JJ Chiu, Chan TF, Tian XY & Huang Y (2022) SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis. Journal of Advanced Research (In press)

  • Huo M, Cao X, Zhang H, Lau CW, Hong H, Chen FM, Huang Y, Chawla A & Tian XY (2022) Loss of Myeloid Bmal1 Exacerbates Hypertensive Vascular Remodelling Through Interaction with STAT6 in Mice. Cardiovascular Research 2021 Nov 2:cvab336. doi: 10.1093/cvr/cvab336. Online ahead of print.

  • Luo JY, Cheng CK, He L, Pu Y, Zhang Y, Lin X, Xu A, Lau CW, Tian XY, Ma RCW, Jo H & Huang Y (2022) Endothelial UCP2 is a mechanosensitive suppressor of atherosclerosis. Circulation Research 131(5):424-441.

  • Zhang H, Xiang L, Huo M, Wu Y, Yu M, Lau CW, Tian D, Gou L, Huang Y, Luo JY, Wang L, Song W, Huang J, Cai Z, Chen S, Tian XY & Huang Y (2022)  Branched-chain amino acid supplementation Impairs Insulin Sensitivity and Promotes Lipogenesis During Exercise in Diet-Induced Obese Mice. Obesity (Silver Spring). 30(6):1205-1218.

  • Zhao L, Zhang CL, He L, Chen QH, Liu L, Kang L, Liu J, Luo JY, Gou L, Qu D, Song W, Lau CW, Ko H, Mok VCT, Tian XY, Wang L & Huang Y (2022) Restoration of Autophagic Flux Improves Endothelial Function in Diabetes Through Reducing Mitochondrial ROS-mediated eNOS Monomerization. Diabetes 71(5):1099-1114.
  • Ma Z, Li X, Fan RLY, Yang KY, Ng CSH, Lau RWH, Wong RHL, Ng KK, Wang CC, Ye P, Fu Z, Chin AWH, Lai MYA, Huang Y, Tian XY, Poon LLM, Lui KO (2022) A human pluripotent stem cell-based model of SARS-CoV-2 infection reveals an ACE2-independent inflammatory activation of vascular endothelial cells through TLR4. Stem Cell Reports 17(3):538-555.
  • Wu Y, Tang X, Lee S, Hong H, Cao X, Lau CW, Liu B, Chawla A, Ma RCW, Huang Y, Lui KO, Tian XY (2022).Endothelial PPARδ facilitates the post-ischemic vascular repair through interaction with HIF1α. Theranostics 12(4):1855-1869.
  • Teoh YCJ, Tian XY, Wong YPC, Lau CW, Cheng CK, Tang WLV, Chan CKR, Huang Y & Ng CF (2022) Endothelial dysfunction after androgen deprivation therapy and the possible underlying mechanisms. Prostate 82(1):13-25.
  • Cheng CK, Luo JY, Lau CW, Cho WCS, Ng CF, Ma RCW, Tian XY & Huang Y (2021) A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction. Acta Pharmacological Sinica 42(10):1598-1609.
  • Zhao L, Li Z, Vong JSL, Chen X, Lai HM, Yan LYC, Huang J, Sy SKH, Tian XY, Huang Y, Chan HYE, So HC, Ng WL, Tang Y, Lin WJ, Mok VCT & Ko H (2020) Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain. Nature Communications (2020)11:4413 (15 pages) https://doi.org/10.1038/s41467-020-18249-3.
  • Liang C, Yang KY, Chan VW, Li X, Fung THW, Wu Y, Tian XY, Lau J, Huang Y, Qin L & Lui KO (2020) CD8+ T-cell plasticity regulates vascular regeneration in type-2 diabetes. Theranostics 10(9):4217-4232.

  • Cheng CK, Luo JY, Lau CW, Chen ZY, Tian XY & *Huang Y (2020)Pharmacological Basis and New Insights of Resveratrol Action in the Cardiovascular System. British Journal of Pharmacology 177(6):1258-1277.
  • Qu D, Wang L, Huo M, Song W, Lau CW, Xu J, Xu A, Yao X, Chiu JJ, Tian XY & Huang Y (2020) Focal TLR4 activation mediates disturbed flow-induced endothelial inflammation. Cardiovascular Research 116(1):226-236. doi: 10.1093/cvr/cvz046.
  • Qu D, Huo M, Wang L, Lau CW, Tian XY & Huang Y (2019) Nilotinib activates endothelial TLR4 to exacerbate atherosclerosis. bioRxiv (Cold Spring Harbor Laboratory), doi: https://doi.org/10.1101/2019.12.14.876599
  • Song W, Zhang CL, Gou L, He L, Gong YY, Qu D, Zhao L, Jin N, Chan TF, Wang L, Tian XY, *Luo JY & *Huang Y (2019) Endothelial TFEB (Transcription Factor EB) Restrains IKK (IκB Kinase)-p65 Pathway to Attenuate Vascular Inflammation in Diabetic db/db Mice. Arteriosclerosis, Thrombosis and Vascular Biology 39(4):719-730.
  • Cheang WS, Wong WT, Wang L, Cheng CK, Lau CW, Ma RCW, Xu A, Wang N, *Huang Y & *Tian XY (2018) Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ.Pharmacological Research 139:384-394.
  • Zhang L, Tian XY, Chan C, Bai Q, Cheng CK, Chen F, Cheung M, Yin B, Yang H, Yung WY, Chen Z, Ding F, Leung K, Zhang C, Huang Y, Lau YW & Choi CH (2018) Promoting the delivery of nanoparticles to atherosclerotic plaques by DNA coating. ACS Applied Materials & Interfaces 11(15):13888-13904.
  • Yang J, Wong LY, Tian XY, Wei R, Lai WH, Au KW, Luo Z, Ward C, Ho WI, Ibañez DP, Liu H, Bao X, Huang Y, Esteban MA & Tse HF  (2018) A familial hypercholesterolemia human liver chimeric mouse model using induced pluripotent stem cell-derived hepatocytes. Journal of Visualized Experiments (139), e57556 (Co-first author)
  • Xiang L, Zhang H, Wei J, Tian XY, Luan H, Li S, Zhao H, Cao G, Chung ACK, Yang C, Huang Y & Cai Z (2018) Metabolomics studies on db/db diabetic mice in skeletal muscle reveal effective clearance of overloaded intermediates by exercise. Analytica Chimica Acta 1037:130-139.
  • *Tian XY, Ma S, Tse GA, Wong WT & Huang Y (2018) Uncoupling protein 2 in cardiovascular health and disease. Frontiers in Physiology (Vascular Physiology) Volume 9:; Article 1060 (13 pages)
  • Leung OM, Li J, Li X, Chan V, Yang KY, Ku M, Lu J, Sun H, Waldmann H, Tian XY, Huang Y, Lau J, Zhou B & Lui KO (2018) Regulatory T-cells promote apelin-mediated sprouting angiogenesis in type-2 diabetes. Cell Reports 24(6):1610-1626.
  • Gou L, Zhao L, Song W, Wang L, Liu J, Zhang H, Huang Y, Lau CW, Yao XQ, Tian XY, Wong WT, Luo JY & Huang Y (2018) Inhibition of miR-92a suppresses oxidative stress and improves endothelial function by upregulating heme oxygenase-1 in db/db mice. Antioxidants & Redox Signaling 28(5):358-370.
  • Chan KW, Zhang L, Cheng CK, Yang H, Huang Y, Tian XY & Choi CH (2018) Recent advances in managing atherosclerosis via nanomedicine. Small 14(4):1702793 (16 pages) (Co-responding author)
  • Xiang L, Wei J, Tian XY, Wang B, Chan W, Li S, Tang Z, Zhang H, Cheang WS, Zhao Q, Zhao H, Yang Z, Hong Y, Huang Y & Cai Z. (2017) Comprehensive analysis of acylcarnitine species in db/db mouse using a novel method of high resolution parallel reaction monitoring reveals widespread metabolic dysfunction induced by diabetes. Analytical Chemistry 89(19):10368-10375.
  • Yang J, Wang Y, Zhou T, Wong LY, Tian XY, Hong X, Lai WH, Au KW, Wei R, Liu Y, Cheng LH, Liang G, Huang Z, Fan W, Zhao P, Wang X, Ibanez DP, Luo Z, L\i Y, Chen S, Wang D, Qin B, Siu CW, Huang Y, Esteban MA & Tse HF (2017) Generation of a human liver chimeric mouse model with hepatocytes derived from familiar hypercholesterolemia induced pluripotent stem cells. Stem Cell Reports. 8(3):605-618.

  • Huo M, Huang YH, Qu D, Zhang H, Wong WT, Chawla A, Huang Y & *Tian XY (2017) Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis. FASEB Journal 31(3):1097-1106.

  • Cheang WS, Wong WT, Zhao L, Xu J, Wang L, Lau CW, Chen ZY, Ma RCW, Xu A, Wang N, *Tian XY & *Huang Y (2017) PPARδ Is required for exercise to attenuate endoplasmic reticulum stress and endothelial dysfunction in diabetic mice. Diabetes 66(2):519-528.

  • Wang L, Luo JY, Li B, Tian XY, Chen LJ, Huang Y, Liu J, Deng D, Lau CW, Wan S, Ai D, Mak KL, Tong KK, Kwan KM, Wang N, Chiu JJ, Zhu Y & Huang Y (2016) Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow.Nature 540:579-581. Commented in Nature News and Views, Nature 540:531-532.

  • Tse G, Yan BP, Chan YWF, Tian XY & Huang Y (2016) Reactive oxygen species, endoplasmic reticulum stress and mitochondrial dysfunction: the link with cardiac arrhythmogenesis. Frontiers in Physiology 7:article 313.

  • Leung FP, Yung LM, Ngai CY, Cheang WS, Tian XY, Lau CW, Zhang Y, Liu J, Chen ZY, Bian ZX, Yao X & Huang Y (2016) Chronic black tea consumption improves endothelial function in ovariectomized rats. European Journal of Nutrition 55(5):1963-1972.

  • Tian XY, Wong WT, Lau CW, Wang YX, Cheang WS, Liu J, Lu Y, Huang H, Xia Y, Chen ZY, Mok CSD, Lau CM & Huang Y (2016) Melamine impairs renal and vascular function in rats. Scientific Reports 6:28041

  • Tian XY, Ma S, Huang Y & Wong WT (2016) A revisit of the renin-angiotensin system in cardiovascular biology. Trends in Cardiovascular Medicine 26(3):229-231.

  • Ma S, Tian XY, Zhang Y, Mu C, Shen H, Bismuth J, Pownall HJ, Huang Y & Wong WT (2016) E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis. Scientific Reports 2016 Mar 9;6:22910. doi: 10.1038/srep22910. (Co-first author)

  • Hu W, Zhang Y, Wang L, Lau CW, Xu J, Luo JY, Gou L, Yao XY, Chen ZY, Ma RCW, Tian XY & Huang Y (2016) Bone morphogenic protein 4-Smad induced upregulation of platelet-derived growth factor AA impairs endothelial function. Arteriosclerosis, Thrombosis and Vascular Biology 36(3):553-560.

  • Tian XY, Ganeshan K, Hong C, Nguyen KD, Qiu Y, Kim J, Tangirala RK, Tontonoz P, Chawla A (2016) Thermoneutral housing accelerates metabolic inflammation to potentiate atherosclerosis but not insulin resistance. Cell Metabolism 23(1):165-178. doi: 10.1016/j.cmet.2015.10.003. 

  • Zhang Y, Liu J, Luo JY, Tian XY, Cheang WS, Xu J, Lau CW, Wang L, Wong WT, Wong CM, Lan HY, Yao XQ, Raizada MK & Huang Y (2015) Upregulation of angiotensin (1-7)-mediated signaling preserves endothelial function through reducing oxidative stress in diabetes. Antioxidants & Redox Signaling 23(11):880-892 with Cover Image of the Issue.

  • Cheang WS, Tian XY, Wong WT, Huang Y (2015) Peroxisome proliferator-activated receptors in cardiovascular diseases: experimental benefits and clinical challenges. British Journal of Pharmacology 172(23):5512-5522.

  • Cheang WS, Ngai CY, Tam YY, Tian XY, Wong WT, Zhang Y, Lau CW, Chen ZY, Bian ZX, Huang Y & Leung FP (2015) Black tea protects against hypertension-associated endothelial dysfunction through alleviation of endoplasmic reticulum stress. Scientific Reports 5:10340

  • Liu J, Wang L, Tian XY, Liu LM, Wong WT, Zhang Y, Han Q, Ho HM, Wang N, Wong SL, Chen ZY, Yu J, Ng CF, Yao X & Huang Y (2015) Unconjugated bilirubin mediates heme oxygenase-1-induced vascular benefits in diabetic mice. Diabetes 64(5):1564-1577

  • Qiu Y, Nguyen KD, Odegaard JI, Cui X, Tian XY, Locksley RM, Palmiter RD, Chawla A (2014) Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 157(6):1292-308

  • Liu L, Liu J, Tian XY, Wong WT, Lau CW, Xu A, Xu G, Ng CF, Yao X, Gao Y & Huang Y (2014) Uncoupling protein-2 up-regulation and oxidative stress inhibition mediate DPP-4 inhibition-induced restoration of endothelial function in hypertension. Antioxidants & Redox Signaling 21(11):1571-1581

  • Cheang WS, Tian XY, Wong WT, Lau CW, Lee ST; Chen ZY, Yao X, Wang N & Huang Y (2014) Metformin protects endothelial function in diet-Induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor δ pathway. Arteriosclerosis, Thrombosis and Vascular Biology 34(4):830-6

  • Liu YH, Tian XY, Huang Y & Wang NP (2014) Rosiglitazone attenuated endothelin-1-induced vasoconstriction of pulmonary arteries in the rat model of pulmonary arterial hypertension. PPAR Research 2014(2014):374075

  • Zhang Y, Liu J, Tian XY, Wong WT, Chen Y, Wang L, Luo JY, Cheang WS, Lau CW, Kwan KM, Wang N, Yao X & Huang Y (2014) Inhibition of bone morphogenic protein-4 restores endothelial function in db/db diabetic mice. Arteriosclerosis, Thrombosis and Vascular Biology 34(1):152-159

  • Cheang WS, Fang X, Tian XY (2013) Pleiotropic Effects of Peroxisome Proliferator-activated Receptor γ and δ in Vascular Diseases. Circulation Journal 77(11):2664-71.

  • Lau YS, Tian XY, Mustafa MR, Murugan D, Liu J, Zhang Y, Lau CW & Huang Y (2013) Boldine improves endothelial function in diabetic db/db mice through inhibiting angiotensin II-mediated BMP4 oxidative stress cascade. British Journal of Pharmacology 170(6):1190-1198

  • Yung LM, Tian XY, Wong WT, Leung FP, Yung LH, Chen ZY, Lau CW, Yao YX & Huang Y (2013) Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats. European Journal of Nutrition 52(3):1145-1155.

  • Wong WT, Tian XY & Huang Y (2013) Endothelial dysfunction in diabetes and hypertension: cross talk in RAS, BMP4 and ROS-dependent COX-2-derived prostanoids. Journal of Cardiovascular Pharmacology (Invited) 61(3):204-214

  • Cheang WS, Lam MY, Wong WT, Tian XY, Zhu Z, Yao X & Huang Y (2013) Menthol relaxes rat aortae, mesenteric and coronary arteries by blocking L-type calcium channels. European Journal of Pharmacology 702(1-3):79-84

  • Liu Y, Tian XY, Mao G, Fang X, Fung ML, Shyy JYJ, Huang Y & Wang N (2013) Letter to the Editor Response: Peroxisome proliferator-activated receptorg ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor. Hypertension 61(4):e30.

  • Lau YS, Tian XY, Huang Y, Murugan D, Achike FI & Mustafa MR (2013) Boldine protects endothelial function in streptozotocin-induced diabetic rats through inhibition of oxidative stress. Biochemical Pharmacology 85(3):367-375

  • Liang YT, Tian XY, Peng C, Ma KY, Chen J, Zuo Y, Jiao R, Lu Y, Huang Y & Chen ZY (2013) Capsaicinoids decrease serum cholesterol, increase sterol excretion and improve endothelial function in hamsters fed a high cholesterol diet. European Journal of Nutrition 52(1):379-388

  • Tian XY, Wong WT, Wang N, Lu Y, Cheang WS, Liu J, Liu L, Liu Y, Lee SST, Chen ZY, Cooke JP & Huang Y (2012) PPARδ activation protects endothelial function in diabetic mice. Diabetes61(12):3285-3293

  • Bi CWC, Xu L, Tian XY, Liu J, Lau CW, Zheng KYZ, Lau DTW, Choi RCY, Dong TTX, Huang Y, Tsim KWK (2012) Fo Shou San, an ancient Chinese herbal decoction, protects endothelial function through increasing endothelial nitric oxide synthase activity. PLoS One 7(12):e51670

  • Liu Y, Tian XY, Mao G, Fang X, Fung ML, Shyy JYJ, Huang Y & Wang N (2012) Peroxisome proliferator-activated receptor g ameliorates pulmonary arterial hypertension by inhibiting 5-HT2B receptor. Hypertension 60(6):1471-1478

  • Chen L, Miao Y, Zhang Y, Dou D, Liu L, Tian XY, Yang G, Pu D, Zhang X, Kang J, Gao Y, Wang S, Breyer MD, Wang N, Zhu Y, Huang Y, Breyer RM, Guan Y (2012) Inactivation of prostaglandin E2 receptor subtype 3 attenuates the angiotensin II pressor response via decreasing arterial contractility. Arteriosclerosis, Thrombosis and Vascular Biology 32(12):3024-3032

  • Liu L, Liu J, Wong WT, Tian XY, Lau CW, Wang YX, Xu G, Pu Y, Zhu Z, Xu A, Lam KSL, Chen ZY, Ng CF, Yao X & Huang Y (2012) Dipeptidyl-peptidase inhibition improves endothelial function and reduces blood pressure in spontaneously hypertensive rats. Hypertension 60(3):833-841

  • Tian, XY, Wong WT, Xu A, Lu Y, Zhang Y, Wang L, Cheang WS, Wang Y, Yao X & Huang Y (2012) Uncoupling protein-2 protects endothelial dysfunction in diet-induced obese mice. Circulation Research 110:1211-1216

  • Chen JN, Jiang Y, Liang YT, Tian XY, Peng C, Ma KY, Liu J, Huang Y & Chen ZY (2012) DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and aortic function in hamsters fed a high cholesterol diet. Atherosclerosis 221(2):397-404

  • Chan YC, Leung FP, Tian XY, Yung LM, Lau CW, Chen ZY, Yao X, Laher I & Huang Y (2012) Raloxifene improves vascular reactivity in pressurized septal coronary arteries of ovariectomized hamsters fed cholesterol diet. Pharmacological Research 65(20):182-188

  • Tian XY, Wong WT, Sayed N, Luo J, Tsang SY, Bian ZX, Lu Y, Cheang WS, Yao X, Chen ZY & Huang Y (2012) NaHS relaxes rat cerebral artery in vitro via inhibition of L-type voltage-sensitive Ca2+ channel. Pharmacological Research 65(20):239-246

  • Tian XY, Wong WT, Leung FP, Zhang Y, Wang YX, Lee HK, Ng CF, Chen ZY, Yao X, Au CL, Lau CW, Vanhoutte PM, Cooke JP & Huang Y (2012) Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin F2a impairs endothelial function in renovascular hypertensive rats Antioxidants & Redox Signaling 16(4):363-373

  • Tian XY, Yung LH, Wong WT, Leung FP, Liu LM, Chen YC, Kong SK, Kwan KM, Ng SM, Lai PB, Yung LM, Yao X & Huang Y (2012) Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway. Journal of Molecular and Cellular Cardiology 52(1):237-244

  • Liang YT, Wong WT, Guan L, Tian XY, Ma KY, Huang Y & Chen ZY (2011) Effect of phytosterols and their oxidation products on lipoprotein profiles and vascular function in hamster fed a high cholesterol diet. Atherosclerosis 219(1):124-133

  • Cheang WS, Wong WT, Tian XY, Yang Q, Lee HK, He GW, Yao X & Huang Y (2011) Endothelial nitric oxide synthase enhancer AVE3085 restores endothelial function and reduces oxidative stress in type 2 diabetic db/db mice. Cardiovascular Research 92(2):267-275

  • Tian XY, Wong WT, Xu A, Chen ZY, Lu Y, Liu L, Lee VWY, Lau CW, Yao X & Huang Y (2011) Rosuvastatin improves endothelial function of db/db mice: Role of angiotensin II type 1 receptors and oxidative stress. British Journal of Pharmacology 164(b):598-606

  • Wong WT, *Tian XY, Xu A, Jun Y, Lau CW, Hoo RLC, Wang Y, Lee VWY, Lam KSL, Vanhouttee PM & Huang Y (2011) Adiponectin is required for PPARg-mediated improvement of endothelial function in diabetic mice. Cell Metabolism 14(1):104-115. (*Co-first author)

  • Yang Q, Xue HM, Wong WT, Tian XY, Huang Y, Tsui SKW, Ng PKS, Wohlfart P, Li H, Xia N, Tobias S, Underwoord MJ & He GW (2011) Endothelial nitric oxide synthase enhancer AVE3085 restores endothelial function and reduces blood pressure in spontaneously hypertensive rats. British Journal of Pharmacology 163(5):1078-1085

  • Yuen CY, Wong WT, Tian XY, Wong SL, Lau CW, Yu J, Tomlinson B, Yao X & Huang Y (2011) Telmisartan inhibits vasoconstriction via PPARγ-dependent expression and activation of endothelial nitric oxide synthase. Cardiovascular Research 90(1):122-129

  • Yung LM, Wong WT, Tian XY, Leung FP, Chen ZY, Lau CW, Yao X & Huang Y (2011) Inhibition of renin-angiotensin system reverses endothelial dysfunction and oxidative stress during estrogen deficiency in ovariectomized rats. PloS One 6(3):e17437

  • Wong WT, *Tian XY, Chen YC, Leung FP, Liu L, Lee HK, Ng CF, Xu A, Yao X, Vanhoutte PM, Tipoe GL & Huang Y (2010) Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: Implications on hypertension. Circulation Research 107(5):984-991. (*Co-first author)

  • Han WQ, Wong WT, Tian XY, Wu LY, Huang Y, Zhu DL & Gao PJ (2010) Contributory role of endothelium and voltage-gated potassium channels in apocynin-induced vasorelaxations. Journal of Hypertension 28(10):2102-2110

  • Cheang WS, Wong WT, Shen B, Lau CW, Tian XY, Tsang SY, Yao X, Chen ZY & Huang Y (2010) 4-Aminopyridine-sensitive K+ channels contributes to NaHS-induced membrane hyperpolarization and relaxation in the rat coronary artery. Vascular Pharmacology 53(3-4):94-98

  • Wong WT, *Tian XY, Xu A, Ng CF, HK Lee, CL Au, Chen ZY, Yao X & Huang Y (2010) Angiotensin II type 1 receptor-dependent oxidative stress modulates endothelial dysfunction in aortas of diabetes mice and humans. Antioxidants & Redox Signaling 16(3):757-768. (*Co-first author)

  • Tian J, Wong WT, *Tian XY, Zhang P, Huang Y & Wang NP (2010) Rosiglitazone attenuates endothelin-1-induced vasoconstriction by up-regulating endothelial expression of ETB receptor. Hypertension 56(1):129-135. (*Co-first author)

  • Wong WT, Wong SL, Tian XY & Huang Y (2010) Endothelial dysfunction: the common consequence in diabetes and hypertension. Journal of Cardiovascular Pharmacology 55(4):300-307

  • Chan YC, Leung FP, Wong WT, *Tian XY, Yung LM, Lau CW, Tsang SY, Yao Y, Chen ZY, Huang Y (2010) Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent eNOS activation. Arteriosclerosis, Thrombosis and Vascular Biology 30(5):992-999. (*Co-first author)

  • Liu CQ, Wong SL, Leung FP, Tian XY, Lau CW, Lu LM, Yao X, Chen ZY, T Yao & Huang Y (2010) Phosphodiesterase inhibition ameliorates prostanoid TP receptor-mediated impairment of vasorelaxation induced by cyclic AMP-elevating dilator. European Journal of Pharmacology 632(1):45-51

  • Yung, LM, Leung, FP, Wong, WT, Tian, XY, Yung, LH, Chen, ZY, Yao, XQ, Huang, Y (2008) Tea polyphenols benefit vascular function. Inflammopharmacology 16(5): 230-234

  • Tian XY, Bian ZX, Hu XG, Zhang XJ, Liu L, Zhang H (2006) Electro-acupuncture attenuates stress-induced defecation in rats with chronic visceral hypersensitivity via serotonergic pathway. Brain Research. 9;1088(1):101-8