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Dr Wing Tak WONG, Jack

PhD (2005-2009); Postdoctoral Research Fellow (2009-2010) Institute of Vascular Medicine and Department of Physiology, Chinese University of Hong Kong, Hong Kong

The American Heart Association Postdoctoral Research Fellow at Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, USA (2011-2013)

The Scientist at Department of Cardiovascular Sciences, Houston Methodist Research Institute, Texas, and Assistant Professor of Vascular and Stem Cell Biology, Department of Cardiothoracic Surgery, Weill Cornell Medical College of Cornell University, USA (2013-2017)

Currently The Assistant Professor at School of Life Sciences, Faculty of Science, Chinese University of Hong Kong

http://www.houstonmethodist.org/wing-tak-jack-wong-phd

 
SCI-indexed publications

  • Cheang WS, Wong WT, Wang L, Cheng CK, Lau CW, Ma RCW, Xu A, Wang N, Huang Y & Tian XY (2018) Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ. Pharmacological Research 139:384-394.

  • Tian XY, Ma S, Tse Ga, Wong WT & Huang Y (2018) Uncoupling protein 2 in cardiovascular health and disease. Frontiers in Physiology (Vascular Physiology) (Accepted)
  • Gou L, Zhao L, Song W, Wang L, Liu J, Zhang H, Huang Y, Lau CW, Yao XQ, Tian XY, Wong WT, Luo JY & Huang Y (2017) Inhibition of miR-92a suppresses oxidative stress and improves endothelial function by upregulating heme oxygenase-1 in db/db mice. Antioxidants & Redox Signaling 28(5):358-370.
  • Cheang WS, Wong WT, Zhao L, Xu J, Wang L, Lau CW, Chen ZY, Ma RCW, Xu A, Wang N, Tian XY & Huang Y (2017) PPARδ Is required for exercise to attenuate endoplasmic reticulum stress and endothelial dysfunction in diabetic mice.Diabetes 66(2):519-528.
  • Huo M, Huang YH, Qu D, Zhang H, Wong WT, Chawla A, Huang Y & Tian XY (2016) Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis.FASEB Journal 31(3):1097-1106.
  • Tian XY, Wong WT, Lau CW, Wang YX, Cheang WS, Liu J, Lu Y, Huang H, Xia Y, Chen ZY, Mok CSD, Lau CM & Huang Y (2016) Melamine impairs renal and vascular function in rats. Scientific Reports 6:28041
  • Tian XY, Ma S, Huang Y & Wong WT (2016) A revisit of the renin-angiotensin system in cardiovascular biology. Trends in Cardiovascular Medicine 26(3):229-231.
  • Ma S, Tian XY, Zhang Y, Mu C, Shen H, Bismuth J, Pownall HJ, Huang Y & Wong WT (2016) E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis. Scientific Reports 2016 Mar 9;6:22910. doi: 10.1038/srep22910.
  • Cheang WS, Tian XY, Wong WT, Huang Y (2015) Peroxisome proliferator-activated receptors in cardiovascular diseases: experimental benefits and clinical challenges. British Journal of Pharmacology 172(23):5512-5522.
  • Zhang Y, Liu J, Luo JY, Tian XY, Cheang WS, Xu J, Lau CW, Wang L, Wong WT, Wong CM, Lan HY, Yao XQ, Raizada MK & Huang Y (2015) Upregulation of angiotensin (1-7)-mediated signaling preserves endothelial function through reducing oxidative stress in diabetes. Antioxidants & Redox Signaling 23(11):880-892 with Cover Image of the Issue.
  • Cheang WS, Ngai CY, Tam YY,  Tian XY, Wong WT, Zhang Y, Lau CW, Chen ZY, Bian ZX, Huang Y & Leung FP (2015) Black tea protects against hypertension-associated endothelial dysfunction through alleviation of endoplasmic reticulum stress. Scientific Reports 5:10340 
  • Liu J, Wang L, Tian XY, Liu LM, Wong WT, Zhang Y, Han Q, Ho HM, Wang N, Wong SL, Chen ZY, Yu J, Ng CF, Yao X & Huang Y (2014) Unconjugated bilirubin mediates heme oxygenase-1-induced vascular benefits in diabetic mice. Diabetes 64(5):1564-1577 with commentary 64(5):1506-1508.
  • Cheang WS, Tian XY, Wong WT, Lau CW, Lee ST; Chen ZY, Yao X, Wang N & Huang Y (2014) Metformin protects endothelial function in diet-Induced obese mice by inhibition of endoplasmic reticulum stress through 5' adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor £_ pathway. Arteriosclerosis, Thrombosis and Vascular Biology 34(4):830-6
  • Liu L, Liu J, Tian XY, Wong WT, Lau CW, Xu A, Xu G, Ng CF, Yao X, Gao Y & Huang Y (2014) Uncoupling protein-2 up-regulation and oxidative stress inhibition mediate DPP-4 inhibition-induced restoration of endothelial function in hypertension. Antioxidants & Redox Signaling 21(11):1571-1581
  • Zhang Y, Liu J, Tian XY, Wong WT, Chen Y, Wang L, Luo JY, Cheang WS, Lau CW, Kwan KM, Wang N, Yao X & Huang Y (2014) Inhibition of bone morphogenic protein-4 restores endothelial function in db/db diabetic mice. Arteriosclerosis, Thrombosis and Vascular Biology 34(1):152-159
  • Yung LM, Tian XY, Wong WT, Leung FP, Yung LH, Chen ZY, Lau CW, Yao YX & Huang Y (2013) Chronic cranberry juice consumption restores cholesterol profiles and improves endothelial function in ovariectomized rats. European Journal of Nutrition 52(3):1145-1155
  • Wong WT, Tian XY, Huang Y (2013). Endothelial Dysfunction in Diabetes and Hypertension: Cross Talk in RAS, BMP4 and ROS-dependent COX-2-derived Prostanoids. J Cardiovascular Pharmacology (Invited) 61(3):204-214
  • Cheang WS, Lam MY, Wong WT, Tian XY, Zhu Z, Yao X, Huang Y (2013) Menthol relaxes rat aortae, mesenteric and coronary arteries by blocking L-type calcium channels. European Journal of Pharmacology 702(1-3):79-84
  • Tian XY, *Wong WT, Wang NP, Lu Y, Cheang WS, Liu J, Liu L, Liu Y, Lee SS, Chen ZY, Cooke JP, Yao X, Huang Y (2012). PPAR£_ activation protects endothelial function in diabetic mice. Diabetes 61(12):3285-93 (*Co-first author)
  • Liu L, Liu J, Wong WT, Tian XY, Lau CW, Wang YX, Xu G, Pu Y, Zhu ZM, Xu A, Lam KS, Chen ZY, Ng CF, Yao X, Huang Y (2012). Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Protects Endothelial Function in Hypertension through GLP-1 Dependent Mechanism. Hypertension 60(3):833-41
  • Tian XY, *Wong WT, Xu A, Lu Y, Zhang Y, Wang L, Cheang WS, Wang Y, Yao X, Huang Y (2012). Uncoupling Protein-2 Protects Endothelial Function in Diet-Induced Obese Mice. Circulation Research 110(9):1211-6. (*Co-first author)
  • Tian XY, *Wong WT, Wang YX, Leung FP, Ng CF, Wang YX, Lee HK, Yao X, Au CL, Lau CW, Vanhoutte PM, Cooke JP, Huang Y (2012) ROS-stimulated production of cyclooxygenase-2-derived prostaglandin F2a cause endothelial dysfunction and impaired renal blood flow in renovascular hypertensive rats. Antioxidant & Redox Signaling 16(4):363-73. (*Co-corresponding author)
  • Tian XY, Yung LH, Wong WT, Leung FP, Chen YC, Kong SK, Ng SM, Lai PB, Yung LM, Yao X & Huang Y (2012) Bone morphogenic protein-4 induces endothelial cell apoptosis through oxidative stress-dependent p38MAPK and JNK pathway. Journal of Molecular and Cellular Cardiology 52(1):237-44
  • Tian XY, Wong WT, Sayed N, Lau CW, Luo J, Tsang SY, Leung FP, Bian ZX, Yao X, Chen ZY, Huang Y (2012) NaHS relaxes rat and mouse cerebral artery through inhibition of L-type Ca2+ channels. Pharmacological Research 65(20:239-246 (Co-corresponding author)
  • Leung JW, Wong WT, Koon HW, Mo FM, Tam S, Huang Y, Vanhoutte PM, Chung SS, Chung SK (2011). Transgenic Mice Over-Expressing ET-1 in the Endothelial Cells Develop Systemic Hypertension with Altered Vascular Reactivity. PLoS One 6(11):e26994
  • Cheang WS, Wong WT, Tian XY, Yang Q, Lee HK, He GW, Yao X, Huang Y (2011) Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice. Cardiovascular Research 92(2):267-75
  • Wong WT, Tian XY, Xu A, Yu J, Lau CW, Hoo RL, Wang Y, Lee VWY, Lam KS, Vanhoutte PM, Huang Y (2011) Adiponectin is required for PPAR£^-mediated improvement of endothelial function in diabetic mice. Cell Metabolism 2011;14(1):104-15
  • *Wong WT, Tian XY, Chen YC, Leung FP, Liu LM, Lee HK, Ng CF, Xu A, Yao X, Vanhoutte PM, Tipoe GL, Huang Y (2010). Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension. Circulation Research 107(8):984-91 (*Co-corresponding author)
  • Wong WT, Tian XY, Xu A, Ng CF, Lee HK, Chen ZY, Au, CL, Yao X, Huang Y (2010). Angiotensin II type 1 receptor-dependent oxidative stress mediates endothelial dysfunction in diabetic mice. Antioxidants & Redox Signaling 15;13(6):757-68
  • Tian XY, Wong WT, Xu A, Chen ZY, Liu L, Cheang WS, Lee VWY, Lau CW, Yao X & Huang Y (2011) Rosuvastatin Improves Endothelial Function of db/db Mice: Role of Angiotensin II Type 1 Receptors and Oxidative Stress. British Journal of Pharmacology 164(2b):598-606.(Co-corresponding author)
  • Liang YT, Wong WT, Guan L, Tian XY, Ma KY, Huang Y and Chen ZY (2011). Effect of Phytosterols and their Oxidation Products on Lipoprotein Profiles and Vascular Function in Hamster Fed a High Cholesterol Diet. Atherosclerosis. 219(1):124-33
  • Wong WT, Wong SL, Tian XY & Huang Y (2010) Endothelial dysfunction: the common denominator in hypertension and diabetes. Journal of Cardiovascular Pharmacology. 55(4):300-7
  • Wong WT, Ng CH, Tsang SY, Huang Y, Chen ZY (2011). Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. Nutrition, Metabolism and Cardiovascular Diseases 21(3):157-64
  • Wong WT, Huang Y. Angiotensin AT2 receptor as a potential therapeutic target in hypertension (2009). Clinical and Experimental Pharmacology and Physiology 36:3-4
  • Tian J, *Wong WT, Zhang P, Guo Y, Tian XY, Guan Y, Gao W, Huang Y & Wang NP (2010) Rosigiltazone attenuates endothelin-1-induced vascular constriction by up-regulating endothelial expression of ETB receptor. Hypertension. 56(1):129-35. (*Co-first author)
  • Chan YC, Leung FP, *Wong WT, Tian XY, Yung LM, Lau CW, Tsang SY, Yao X, Chen ZY, Huang Y (2010). Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent eNOS activation. Arteriosclerosis, Thrombosis and Vascular Biology30(5):992-9. (*Co-first author)
  • Yang Q, Xue HM, *Wong WT, Tian XY, Huang Y, Tsui SKW, Ng PKS, Wohlfart P, Li H & He GW (2010) Therapeutic Significance of Endothelial Nitric Oxide Synthase Enhancers and Study on Transcriptional Mediators. British Journal of Pharmacology (Accepted) (Co-first author)
  • Yang D, Luo Z, Ma S, Wong WT, Ma L, Feng X, Hao X, Cao T, Zhao Z, Liu D, Arendshorst WJ, Huang Y, Tepel M & Zhu Z (2010) Activation of TRPV1 by Dietary Capsaicin Improves Endothelium-Dependent Vasorelaxation and Prevents Hypertension. Cell Metabolism 4;12(2):130-141. CoverArt Image and editorial previews [Sessa WC Cell Metabolism 2010;12(2):109-110]
  • Zhu ZM, Liu DY, Wong WT & Huang Y (2010) TRPV1, Endothelial Function, Hypertension and Beyond ”V Reply. Cell Metabolism 12(5):422
  • Wong SL, Wong WT, Tian XY, Lau CW, Huang Y (2010) Prostaglandins in action: indispensible roles of cyclooxygenase-1 and -2 in endothelium-dependent contractions. In Advances in Pharmacology 60:61-83.
  • Chang J, Li Y, Huang Y, Lam KS, Hoo RL, Wong WT, Cheng KY, Wang Y, Vanhoutte PM & Xu A (2010). Adiponectin Prevents Diabetic Premature Senescence of Endothelial Progenitor Cells by Suppressing the p38 MAP kinase/p16INK4A Signaling Pathway. Diabetes 59(11):2949-59
  • Yuen CY, Wong WT, Tian XY, Wong SL, Lau CW, Yu J, Tomlinson B, Yao X & Huang Y (2011) Telmisartan inhibits vasoconstriction via PPAR£^-dependent expression and activation of endothelial nitric oxide synthase. Cardiovascular Research 90(1):122-129
  • Wong SL, Lau CW, Wong WT, Xu A, Au CL, Ng CF, Ng SSM, Yao X, Huang Y (2011) Pivotal role of PKC£_ in angiotensin II-induced endothelial cyclooxygenase-2 expression: A link to vascular inflammation. Arteriosclerosis, Thrombosis and Vascular Biology 31(5):1169-1176
  • Yung LM, Wong WT, Tian XY, Leung FP, Chen ZY, Lau CW, Yao X & Huang Y (2011) Inhibition of renin-angiotensin system reverses endothelial dysfunction and oxidative stress during estrogen deficiency in ovariectomized rats. Plos One 6(3):e17437
  • Han W, Wong WT, Tian XY, Huang Y, Wu L, Zhu D, & Gao PJ (2010) Contributory role of endothelium and voltage-gated potassium channels in apocynin-induced vasorelaxations. Journal of Hypertension 28(10):2102-2110
  • Cheang WS, Wong WT, Shen B, Lau CW, Tian XY, Tsang SY, Yao X & Huang Y (2010) 4-Aminopyridine-sensitive K+ channels contributes to NaHS-induced membrane hyperpolarization and relaxation in the rat coronary artery. Vascular Pharmacology 53(3-4):94-98
  • Griffith JF, Wang YX, Zhou H, Kwong WH, Wong WT, Sun YL, Huang Y, Yeung DK, Qin L, Ahuja AT (2010). Likely causes of reduced bone perfusion in osteoporosis: novel findings in an ovariectomy rat model. Radiology 254(3):739-46
  • Liu CQ, Leung FP, Wong SL, Lau CW, Wong WT, Lu LM, Yao X, Yao T, Huang Y (2009). Thromboxane prostanoid receptor activation impairs endothelial nitric oxide-dependent vasorelaxations: the role of Rho kinase. Biochemical Pharmacology 15;78(4):374-81
  • Wang Y, Huang Y, Lam KS, Li Y, Wong WT, Ye H, Lau CW, Vanhoutte PM, Xu A (2009). Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase. Cardiovascular Research 82(3):484-92
  • Yung LM, Leung FP, Wong WT, Tian XY, Yung LH, Chen ZY, Yao XQ, Huang Y (2008). Tea polyphenols benefit vascular function. Inflammopharmacology 16:230-234.
  • Zhong JC, Huang Y, Yung LM, Lau CW, Leung FP, Wong WT, Lin SG, Yu XY (2007). The novel peptide apelin regulates intrarenal artery tone in diabetic mice. Regulatory Peptides 144:109-114
  • Huang Y, Bourreau JP, Chan HY, Lau CW, Wong JWT, Yao X. Inhibitory effect of tetrabutylammonium ions on endothelium/nitric oxide-mediated vasorelaxation (2001). Life Sciences 69:1661-1672