** Recent Selective Representative Publications **

Full List of publications in peer-reviewed SCI-indexed journals

2010

• Zhang DE, Lin SM, Lau CW, Yiu A, Wang J, Li Y, Fan CL, *Huang Y, Ye WC (2010) Anemoside A3-induced relaxation in rat renal arteries: role of endothelium and Ca2+ channel inhibition. Planta Medica 76(16):1814-1819

• Jiao R, Yu FF, Huang Y & Chen ZY (2010) β-Sitosterol decreases but its intake frequency has no effect on plasma cholesterol level. Current Topics in Nutraceutical Resarch 8(4):127-135

• Zhu ZM, Liu DY, Wong WT & Huang Y (2010) Response to Andresen and Peters. Cell Metabolism 12(5):422

• Chang J, Li Y, Huang Y, Lam KSL, Hoo RL, Wong WT, Cheng KK, Wang Y, Vanhoutte PM & Xu A (2010) Adiponectin Prevents Diabetic Premature Senescence of Endothelial Progenitor Cells and Promotes Endothelial Repair by Suppressing the p38 MAP kinase/p16INK4A Signaling Pathway. Diabetes 59(11):2949-2959

• Jiao R, Zhang Z, Yu H, Huang Y & Chen ZY (2010) Hypocholesterolemic activity of grape seed proanthocyanidin is mediated by 3 enhancement of bile acid excretion and up-regulation of CYP7A1. Journal of Nutritional Biochemistry 21(11):1134-1139

• Ma X, Cao J, Luo J, Nilius B, Huang Y, Ambudkar IS & Yao X (2010) Depletion of intracellular Ca2+ stores stimulates the translocation of TRPV4-C1 heteromeric channels to the plasma membrane. Arteriosclerosis, Thrombosis and Vascular Biology 30(11):2249-2255

• Liu H, Jin M-W, Sun H-Y, Huang Y & Li G-R (2010) The selective estrogen receptor modulator raloxifene inhibits cardiac delayed rectifier potassium currents and voltage-gated sodium current without QTc interval prolongation. Pharmacological Resaerch 62(5):384-390

• Wong WT, Tian XY, Chen YC, Leung FP, Liu L, Lee HK, Ng CF, Xu A, Yao X, Vanhoutte PM, Tipoe GL & *Huang Y (2010) Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: Implications on hypertension. Circulation Research 107(5):984-991

• Han WQ, Wong WT, Tian XY, Wu LY, Huang Y, Zhu DL & Gao PJ (2010) Contributory role of endothelium and voltage-gated potassium channels in apocynin-induced vasorelaxations. Journal of Hypertension 28(10):2102-2110

• Zhou L, Xue H, Yuan P, Ni J, Yu C, Huang Y & Lu L (2010) Agiotensin II type 1 receptor activation mediates high glucose-Induced rat proximal tubule epithelial mesenchymal transition. Clinical and Experimental Pharmacology and Physiology 37(9):e152-157

• Cheang WS, Wong WT, Shen B, Lau CW, Tian XY, Tsang SY, Yao X, Chen ZY, *Huang Y (2010) 4-Aminopyridine-sensitive K+ channels contributes to NaHS-induced membrane hyperpolarization and relaxation in the rat coronary artery. Vascular Pharmacology 53(3-4):94-98

• Schleifenbaum J, Voblova N, Kohn C, Zavaritskaya O, Dubrovska G, Gloe T, Crean CS, Luft FC, Huang Y, Jentsch T, Schubert R & Gollasch M (2010). Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide Journal of Hypertension 28(9):1875-1882

• Wong WT, Tian XY, Xu A, Ng CF, HK Lee, CL Au, Chen ZY, Yao X & *Huang Y (2010) Angiotensin II type 1 receptor-dependent oxidative stress modulates endothelial dysfunction in aortas of diabetes mice and humans. Antioxidants & Redox Signaling 16(3):757-768

• Yang D, Luo Z, Ma S, Wong WT, Ma L, Feng X, Hao X, Cao T, Zhao Z, Liu D, Arendshorst WJ, Huang Y, Tepel M & Zhu Z (2010) Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension. Cell Metabolism 12(20:130-141 with CoverArt Image and editorial previews [Sessa WC Cell Metabolism 2010;12(2):109-110]

• Tian J, Wong WT, Tian XY, Zhang P, *Huang Y & Wang NP (2010) Rosiglitazone attenuates endothelin-1-induced vasoconstriction by up-regulating endothelial expression of ETB receptor. Hypertension 56(1):129-135

• Leung YK, Du J, Huang Y & Yao X (2010) Cyclic nucleotide-gated channels contribute to thromboxane A2-induced contraction of rat small mesenteric arteries. PLoS One 5(6):e11098.

• Feletou M, Huang Y & Vanhoutte PM (2010) Vasoconstrictor prostanoids. In The Endothelial Saga: The Heritage of Robert F. Furchgott" Special Issue Pflugers Archiv European Journal of Physiology (Invited Review) 459(6):941-950

• Jiao R, Guan L, Yang N, Peng C, Liang Y, Ma KY, Huang Y & Chen ZY (2010) Frequent Cholesterol Intake Up-regulates Intestinal NPC1L1, ACAT2, and MTP. Journal of Agricultural and Food Chemistry 58(9):5851-5857

• Kong EK, Huang Y, Sanderson JE, Chan KB, Yu S & Yu CM (2010) Baicalein and wogonin inhibit collagen deposition in SHR and WKY cardiac fibroblast cultures. BMB Reports 43(4):297-303

• Wong WT, Wong SL, Tain XY & *Huang Y (2010) Endothelial dysfunction: the common consequence in diabetes and hypertension. Journal of Cardiovascular Pharmacology 55(4):300-307

• Zhang Man, Leung FP, *Huang Y & Bian ZX (2010) Up-regulation of L-type calcium channel mediates increased contractility of colonic smooth muscle in a rat model of irritable bowel syndrome. Neurogastroenterology & Motility 22(5):e162-e170

• Chan YC, Leung FP, Wong WT, Tian TY, Yung LM, Lau CW, Tsang SY, Yao Y, Chen ZY & *Huang Y (2010) Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent eNOS activation. Arteriosclerosis, Thrombosis and Vascular Biology 30(5):992-999

• Wong SL & *Huang Y (2010) Adventitial connection to outside-in regulation of vascular function. Invited editorial commentary. Circulation Journal 74(5):854-855

• Wong CO, Huang Y & Yao X (2010) Genistein potentiates activity of the cation channel TRPC5 independently of tyrosine kinases. British Journal of Pharmacology 159(7):1486-1496

• Ma X, Qiu S, Luo JH, Ma Y, Ngai CY, Shen B, Wong CO, Huang Y & Yao XQ (2010) Functional role of TRPV4-TRPC1 complex in flow-induced Ca2+ influx. Arteriosclerosis, Thrombosis, and Vascular Biology. 30(4):851-858

• Yip KH, Leung FP, Huang Y & Lau HY (2010) The nitric oxide donor, diethylamine NONOate, inhibits human mast cell activation through a guanosine 3’,5’-cyclic monophosphate dependent pathway. European Journal of Pharmacology 632(1-3):86-92

• Liu CQ, Wong SL, Leung FP, Tian XY, Lau CW, Lu LM, Yao X, Chen ZY, T Yao & *Huang Y (2010) Phosphodiesterase inhibition ameliorates prostanoid TP receptor-mediated impairment of vasorelaxation induced by cyclic AMP-elevating dilator. European Journal of Pharmacology 632(1):45-51

• Chen ZW, Yang Q, Huang Y, Fan L, Li XW & He GW (2010) Human urotensin II in internal mammary and radial arteries of patients undergoing coronary surgery. Vascular Pharmacology 52(1-2):70-76

• Griffith JF, Wang YX, Zhou H, Kwong WH, Wong WT, Sun YL, Huang Y, Yeung DKW, Qin L & Ahuja AT (2010) Likely causes of reduced bone perfusion in osteoporosis: novel findings in an ovariectomy rat model. Radiology 254(3):739-746

• Kwan HY, Cheng KT, Ma Y, Huang Y, Tang NL, Yu S & Yao X (2010) CNGA2 contributes to ATP-Induced noncapacitative Ca influx in vascular endothelial cells. Journal of Vascular Research 47(2):148-156

2009

• Qu L, Xue H, Yuan P, Zhou L, Yao T, Huang Y & Lu L (2009) Adenosine 5′-triphosphate stimulates the increase of TGF-β1 in rat mesangial cells under high-glucose conditions via reactive oxygen species and ERK1/2. Acta Pharmacologica Sinica 30(12):1601-1606

• Peng C, Chan HYE, Li YM, Huang Y & Chen ZY (2009) Black tea theaflavins extend the lifespan of fruit flies. Experimental Gerontology 44(12):773-783

• Ma KY, Zhang ZS, Zhao, S, Chang Q, Wong YM, Yeung SYV, Huang Y & Chen ZY (2009) Red yeast rice increases excretion of bile acids in hamsters. Biomedical and Environmental Sciences 22(4):269-277

• Kwan HY, Huang Y, Yao XQ & Leung FP (2009) Involvement of cyclic nucleotides in the control of cytosolic Ca2+ levels in vascular endothelial cells. Clinical and Experimental Pharmacology and Physiology 36(9):857-866

• Zhang Z, Wang H, Jiao R, Peng C, Wong YM, Yeung VSY Huang Y & Chen ZY (2009) Choosing hamsters but not rats as a model for studying plasma cholesterol-lowering activity of functional foods. Molecular Nutrition & Food Research 53(7):921-930

• Xue H, Yuan P, Zhou L, Yao T, Huang Y & Lu LM (2009) Effect of adrenotensin on cell proliferation is mediated by angiotensin II in cultured rat mesangial cells. Acta Pharmacologica Sinica 30(8):1132-1137

• Liu CQ, Leung FP, Wong SL, Lau CW, Wong WT, Lu L, Yao X, Yao T & *Huang Y (2009) Thromboxane prostanoid receptor activation impairs endothelial nitric oxide-dependent vasorelaxations: the role of Rho kinase. Biochemical Pharmacology 78(4):374-381

• Chen ZY, Peng C, Jiao R, Wong YM, Yang N & Huang Y (2009) Anti-hypertensive nutraceuticals and functional foods. Journal of Agricultural and Food Chemistry 57(11):4485-4499

• Wang Y, Huang Y, Lam KSL, Li Y, Ye H, Lau CW, Vanhoutte P & Xu A (2009) Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via AMP-activated protein kinase and eNOS. Cardiovascular Research (Co-first author) 82(3):484-492

• Yip KH, Leung Fung PL, Huang Y & Lau HY (2009) Inhibition of anti-IgE mediated human mast cell activation by NO donors is dependent on their NO release kinetics. British Journal of Pharmacology 156(8):1279-1286

• Lau HY, Huang Y & Law KY. (2009) Effects of oestrogenic agents on rat peritoneal mast cells. Inflammation Research 58 (Suppl 1):15-16

• Kwan HY, Shen B, Ma X, Kwok YC, Huang Y, Man YB, Yu S & Yao X (2009) TRPC1 associates with BKCa channel to form a signal complex in vascular smooth muscle cells. Circulation Research 104(5):670-678

• He M, Zhang L, Shao Y, Wang X, Huang Y, Yao T & Lu L (2009) Inhibition of renin/prorenin receptor attenuated mesangial cells proliferation and reduced associated proliferative factors. European Journal of Pharmacology 606(1-3):155-161

• Wong SL, Leung FP, Au CL, Yung LM, Lau CW, Yao X, Chen ZY, Vanhoutte PM & *Huang Y (2009) Cyclooxygenase-2-derived PGF2α mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during ageing. Circulation Research 104(2):228-235. With Editorial Commentary (Circ Res 2009;104:141-143

• Wong WT & Huang Y (2009) AT2R as a potential therapeutic target against hypertension. (Editorial Commentary) Clinical and Experimental Pharmacology and Physiology 36(1):3-4

• Leung KW, Leung FP, Mak NK, Tombran-Tink J, *Huang Y & Wong RNS (2009) Protopanaxadiol and protopanaxatriol bind to glucocorticoid and estrogen receptors in endothelial cells. British Journal of Pharmacology 156(4):626-637

• Kwan HY, Wong CO, Chen ZY, Dominic Chan TW, Huang Y & Yao X (2009) Stimulation of histamine H(2) receptors activates TRPC3 channels through both phospholipase C and phospholipase D. European Journal of Pharmacology 602(2-3):181-187

• Hercule HC, Schunck W-H, Gross V, Seringer J, Leung FP, Weldon SM, Andrey Ch, Goncalves da C, Huang Y, Luft FC & Gollasch M (2009) Interaction between P450 eicosanoids and nitric oxide in the control of arterial tone in mice. Arteriosclerosis, Thrombosis and Vascular Biology 29(1):54-60

• Yung LM, Laher I, Yao X, Chen ZY, *Huang Y & Leung FP (2009) Exercise and cardiovascular health – Part II. Sports Medicine 39(1):45-63

2008

• Leung FP, Yung LM, Laher I, Yao X, Chen ZY & *Huang Y (2008) Exercise and cardiovascular health – Part I. Sports Medicine 38(12):1009-1024

• Shen B, Cheng KT, Leung YK, Kwok YC, Kwan HY, Wong CO, Chen ZY, Huang Y & Yao X (2008) Epinephrine-induced Ca2+ influx in vascular endothelial cells is mediated by CNGA2 channels. Journal of Molecular and Cellular Cardiology 45(3):437-445

• Wong CW, Yung LM, Leung FP, Tsang SY, Au CL, Chen ZY, Yao X, Cheng HK, Lau CW, Gollasch M & *Huang Y (2008) Raloxifene protects endothelial cells against oxidative stress. British Journal of Pharmacology 155(3):326-334

• Lam CK, Zhang Z, Yu H, Tsang SY, Huang Y & Chen ZY (2008) Apple polyphenols inhibit plasma CETP activity and reduce the ratio of non-HDL to HDL cholesterol. Molecular Nutrition and Food Research 52(8):950-958

• Liu CQ, Leung FP, Lee WY, Lau CW, Yao Y, Lu Limin & *Huang Y (2008) Prevention of nitroglycerin tolerance in vitro by T0156, a selective phosphodiesterase type 5 inhibitor. European Journal of Pharmacology 590(1-3):250-254

• Shao Y, He M, Zhou L, Yao Y, Huang Y & Lu L (2008) Chronic angiotensin (1–7) injection accelerates STZ-induced diabetic renal injury. Acta Pharmacologica Sinica 29(7):829-837

• Guan L, Huang Y & Chen ZY (2008) Developmental and reproductive toxicity of soybean isoflavones to immature SD rats. Biomedical & Environmental Sciences 21(3):197-204

• Cheng KT, Leung YK, Shen B, Kwok YC, Kwan HY, Wong CO, Ma X, Huang Y, & Yao X (2008). CNGA2 channels mediate adenosine-induced Ca2+ influx in vascular endothelial cells. Arteriosclerosis, Thrombosis and Vascular Biology 28(5):913-918

• Yip KH, Huang Y, Waye MMY & Lau HYA (2008) Induction of nitric oxide synthase isoforms in primary human culture mast cells by IgE and proinflammatory cytokines. International Immunopharmacology 8(5):765-768

• Li YM, Chan HYE, Yao XQ, Huang Y & Chen ZY (2008) Green tea catechins and broccoli reduce fat-Induced mortality in Drosophila melanogaster. Journal of Nutritional Biochemistry 19(6):376-383

• Lam CK, Chen Jingnan, Cao Y, Yang L, Wong YM, Yeung SYV, Yao Y, Huang Y & Chen ZY (2008) Conjugated and non-conjugated octadecaenoic acids after differently intestinal acyl coenzyme A: Cholesterol acyltransferase activity. Atherosclerosis 198(1):85-93

• Leung FP, Yung LM, Yao X, I Laher & *Huang Y (2008) Stored-operated calcium entry in vascular smooth muscle. British Journal of Pharmacology 153(5):846-857

• Li YM, Chan HYE, Huang Y & Chen ZY (2008) Broccoli (Brassica oleracea var. botrytis L.) improves the survival and up-regulates endogenous antioxidant enzymes in Drosophila melanogaster challenged with reactive oxygen species. Journal of the Science of Food and Agriculture 88(3):499-506

• Ng CH, Yao X, Huang Y & Chen ZY, (2008) Oxidized cholesterol Is more hypercholesterolemic and atherogenic than non-oxidized cholesterol in hamsters. British Journal of Nutrition 99(4):749-755

• Wong CM, Tsang SY, Yao XQ, Chan FL & *Huang Y (2008) Effects of estrogen and progesterone on potassium channels expressed in Xenopus oocytes. Steroids 73(3):272-279

2007

• Zhong JC, *Huang Y, Yung LM, Lau CW, Leung FP, Wong WT & Yu XY (2007) The novel peptide apelin regulates intrarenal artery tone in diabetic mice. Regulatory peptides 144:109-114

• Chung HL, Yue GCL, To KF, Su YL, Huang Y & Ko WH (2007) Effect of Scutellariae Radix extract on experimental dextran-sulfate sodium-induced colitis in rats. World Journal of Gastroenterology 13(42):5605-5611

• Kwan HY, Huang Y & Yao X (2007) Cyclic nucleotides and Ca2+ influx pathways in vascular endothelial cells. Clinical Hematology and Microcirculation 37(1-2):63-70

• Leung FP, Yung LM, Leung HS, Au CL, Yao X, Vanhoutte PM, Laher I & *Huang Y (2007) Therapeutic concentrations of raloxifene augments nitric oxide-dependent relaxation in porcine coronary artery.British Journal of Pharmacology 152(2):223-229

• Fesus G, Dubrovska G, Gorzelniak K, Huang Y, Luft FC & Gollasch M (2007) Adiponectin is a novel humoral vasodilator. Cardiovascular Research 75(4):719-727. With Editorial Commentary “The adventitia: The outs and ins of vascular disease” Cardiovasc Res 2007;75(4):636-639

• Wang X-F, Shao Y, Chen S-W, Tian D-Z, Huang G-Y, Huang Y, Yao T & Lu L-M (2007) Attenuation of cardiac dysfunction in rats following administration of non-viral vector carrying adrenomedullin. Clinical and Experimental Pharmacology and Physiology34:861-865

• Kwan HY, Huang Y & Yao X (2007) TRP channels in endothelial function and dysfunction. Biochim Biophys Acta - Molecular Basis of Disease 1772(2):907-914

• Zhou L, Shao Y, Huang Y, Yao T & Lu LM (2007) 17b-Estradiol inhibits angiotensin II-induced collagens synthesis in cultured rat cardiac fibroblasts via modulating angiotensin II receptors. European Journal of Pharmacology 567(3):186-192

• Leung FP, Tsang SY, Yung LM, Wong CM, Chan YC, Leung HS, Yao X & *Huang Y (2007) Raloxifene, tamoxifen and vascular tone. Clinical and Experimental Pharmacology and Physiology (invited article to A Special Issue on Steroid Hormones and Vascular Function) 34:809-813

• Chan YC, Leung FP, Yao X, Lau CW, Vanhoutte PM & *Huang Y. (2007) Raloxifene modulates pulmonary vascular reactivity in spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology 49(6):355-361

• Leung KW, Leung FP, Huang Y, Mak NK & Wong RNS (2007) Non-genomic effects of ginsenoside-Re in endothelial cells via glucocorticoid receptor. FEBS Letters 581(13):2423-2428

• Zhong JX, Yu XY, Huang Y, Yung LM, Lau CW & Lin SG (2007) Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice. Cardiovascular Research 74(3):388-395. With Editorial Commentary “Apelin and vascular dysfunction in type 2 diabetes” Cardiovasc Res 2007;74(3):339-340

• Cheng KKY, Lam KSL, Wang Y, Wu D, Huang Y, Wong C, Sweeney G & Xu A (2007) Adiponectin-induced eNOS activation and nitric oxide production are mediated by APPL1 in endothelial cells. Diabetes 56(5):1387-1394

• Li YM, Chan HYE, Huang Y & Chen ZY (2007) Green tea catechins upregulate superoxide dismutase and catalase in fruit flies. Molecular Nutrition and Food Research 51(5):546-554

• Tang EHC, Leung FP, Huang Y, Feletou M, So KF, Man RYK & Vanhoutte PM (2007) Calcium and reactive oxygen species increase in endothelial cells in response to releasers of endothelium-derived contracting factor. British Journal of Pharmacology 151(1):15-23

• Liu H, Jin MW, Xiang JZ, Huang Y, Chiu SW, Lau CP & Li GR (2007) Raloxifene inhibits transient outward and ultra-rapid delayed rectifier potassium currents in human atrial myocytes. European Journal of Pharmacology 563:61-68

• Tsang SY, Yao XQ, Chan HY, Chan FL, Leung CSL, Yung LM, Au CL, Chen ZY, Laher I & *Huang Y (2007) Tamoxifen and estrogen attenuates enhanced vascular tone induced by estrogen deficiency in rat carotid arteries. Biochemical Pharmacology 73(9):1330-1339

• Leung HS, Seto SW, Kwan YY, Leung FP, Au ALS, Yung LM, Yao X & *Huang Y (2007) Endothelium-independent relaxation to raloxifene in porcine coronary artery. European Journal of Pharmacology 555(2-3):178-184

2006

• Leung HS, Yung LM, Leung FP, Yao X, Chen ZY, Ko WH, Laher I & *Huang Y (2006) Tamoxifen diates porcine coronary arteries: role of nitric oxide and ouabain sensitive mechanisms. British Journal of Pharmacology 149(6):703-711

• Lui K, Huang Y, Choi HL, Yu S, Wong KB, Chen S & Chan FL (2006) Molecular cloning and expression of estrogen receptor-related g receptor in rat prostate gland. Prostate 66:1600-1619

• Liu CL, Huang Y, Ngai CY, Leung YK & Yao XQ (2006) TRPC3 is involved in flow- and bradykinin-induced vasodilation in rat small mesenteric arteries. Acta Pharmacologica Sinica 27(8):981-990

• Lei G, Yeung SYV, Huang Y & Chen ZY (2006) Both soybean and kudzu phytoestrogens modify favorably the blood lipoprotein profile in ovariectomized and castrated hamsters. Journal of Agricultural and Food Chemistry 54(13):4907-4912

• Leung PC, Cheng KT, Liu C, Cheung WT, Kwan HY, Lau KL, Huang Y & Yao X (2006) Mechanism of non-capacitative Ca influx in response to bradykinin in vascular endothelial cells. Journal of Vascular Research 43(4):367-376

• Liu C, Ngai CY, Huang Y, Ko WH, Wu M, He GW, Garland CJ, Dora KA & Yao X (2006) Depletion of intracellular Ca2+ stores enhances flow-induced vascular dilatation in rat small mesenteric artery. British Journal of Pharmacology 147(5):506-515

• Leung HS, Leung FP, Yao X, Ko WH, Chen ZY, Vanhoutte PM & *Huang Y (2006) Endothelial mediators of the acetylcholine-induced relaxation of the rat femoral arteries. Vascular Pharmacology 44(5):299-308

• Wong CM, Yao X, Au CL, Tsang SY, Fung KF, Laher I, Vanhoutte PM & *Huang Y (2006) Raloxifene prevents endothelial function in aging ovariectomized female rats. Vascular Pharmacology 44(5):290-298

• Zhang RZ, Yang Q, Yim APC, Huang Y & He GW (2006) Role of NO and EDHF-mediated endothelial function in the porcine pulmonary circulation: comparison between pulmonary artery and vein. Vascular Pharmacology 44:183-191

• Kwan HY, Huang Y & Yao X (2006) Protein kinase C can inhibit TRPC3 channels indirectly via stimulating protein kinase G. Journal of Cellular Physiology 207(2):315-321

• Leung HS, Yao X, Leung FP, Ko WH, Chen ZY, Gollasch M & *Huang Y (2006) Cilnidipine, a slow-acting Ca2+ channel blocker, induces relaxation in porcine coronary artery: role of endothelial nitric oxide and [Ca2+]i. British Journal of Pharmacology 147(1):55-63

• Yao X, Kwan HY & Huang Y (2006) Regulation of TRP channels by Phosphorylation. Neurosignals 14:273-280

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** 1996-2000 **

** 1987-1995 **