In this work, we applied cyclic compression loading on cultured human osteoarthritic chondrocytes (hOAC)-collagen constructs and measured the expression of the major chondrogenic factors, cell-matrix interaction molecules and matrix degradation enzymes. Our results show that dynamic compression loading stimulates the expression and nuclear localization of Sox9 in hOACs and reduces the catabolic events via downregulated expression of collagenases.
Check out the published paper here: https://doi.org/10.1016/j.bbrc.2017.02.073