Prof. Fung Kwok Pui

Biography

Prof. Fung Kwok Pui

Professor Fung Kwok‑pui is a Permanent Emeritus Professor of The Chinese University of Hong Kong (CUHK), Adjunct Professor at the School of Chinese Medicine, Faculty of Medicine, and Hong Kong Institute of Integrative Medicine, CUHK, as well as Adjunct Professor at the School of Medicine, CUHK (Shenzhen). He is the former Director of the institute of Chinese Medicine (ICM), CUHK and is now serves as Honorary Senior Research Fellow in the ICM.

Professor Fung obtained his undergraduate and master’s degrees from The Chinese University of Hong Kong, and received his Doctor of Philosophy (PhD) from the University of Hong Kong. He joined CUHK in 1978 and has since held numerous academic and administrative positions within the University. He was promoted to Professor of Biochemistry in 2002. Over the years, he has made significant contributions to both teaching and research, particularly in the fields of biochemistry, traditional Chinese medicine, and integrative biomedical sciences.

He previously served as Head of United College, CUHK (2002–2012), Council Member of CUHK, Chairman of the Academic Advisory Committee of the State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants (CUHK), and Associate Director (Administration) of the School of Biomedical Sciences, CUHK.

Currently, Professor Fung holds several leadership roles within CUHK and its affiliated institutions. He is a Trustee of United College and Member of the Board of Directors of Diligentia College, CUHK (Shenzhen). He also serves as Chairman of the Endowment Fund Committee of the Board of Trustees of United College and Chairman of Hok Hoi Library, Hong Kong.

In recognition of his lifelong dedication and achievements in education, research, and university service, Professor Fung was awarded the title of Emeritus Professor by The Chinese University of Hong Kong, effective 1 August 2016.

Research Interests

(1) Traditional Chinese Medicine

(2) Anti-tumor Drug

(3) Photodynamic Therapy

(4) Glucose Transporter

Publications in 2013-2018

  1. Deng, Y., Lam, F.F.Y., Ng, E.S.K., Lau, C.B.S., Koon, J.C.M., Leung, P.C., & Fung, K.P. (2018). A Herbal Formulation of Danshen and Gegen Protects Rat Brains from Injuries Induced by Focal and Global Ischaemia. Journal of Advancements in Plant Science, 1(1), Article 104.
  2. Chu, C.Y., Fung, K.P., & Wang, C.C. (2018). Effects of Low-dose Melamine Exposure during Pregnancy on Maternal and Fetal Kidneys in Rats. Environmental Toxicology, 33(3),370-380.
  3. Li, M., Yue, G.G.L., Tsui, S.K.W., Fung, K.P., & Lau, C.B.S. (2018) Turmeric extract, with absorbable curcumin, has potent anti-metastatic effect in vitro and in vivo. Phytomedicine, 46, 131-141.
  4. Zhou, X., Yue, G.G.L., Tsui, S.K.W., Pu, J., Fung, K.P., & Lau, C.B.S. (2018). Elaborating the role of natural products on the regulation of autophagy and their potentials in breast cancer therapy. Current Cancer Drug Targets, 18 (3), 239-255.
  5. Li, L., Yue, G.G.L., Lee, J.K.M., Wong, E.C.W., Fung, K.P., Yu, J., Lau, C.B.S., & Chiu, P.W.Y. (2018). Gene expression profiling reveals the plausible mechanisms underlying the anti-tumor and anti-metastasis effects of Andrographis paniculata in esophageal cancer. Phytotherapy Research, 32, 1388-1396. doi.org/10.1002/ptr.6074.
  6. Li, M., Yue, G.G.L., Song, L.H., Huang, M.B., Lee, J.K.M., Tsui, S.K.W., Fung, K.P., Tan, N.H., & Lau, C.B.S. (2018). Natural Small Molecule Bigelovin Suppresses Orthotopic Colorectal Tumor Growth and Inhibits Colorectal Cancer Metastasis via IL6/ STAT3 Pathway. Biochemical Pharmacology, 150, 191-201.
  7. Yue, G.G.L., Lee, J.K.M., Chan, B.C.L., Kwok, H.F., Hoi, S.W.H., Sze, D.M.Y., Fung, K.P., Leung, P.C., & Lau, C.B.S. (2018). An innovative anti-cancer Chinese herbal formula exhibited multi-targeted efficacies in metastatic breast cancer mouse model. Chinese Medicine, 13:64. doi.org/10.1186/s13020-018-0222-9.
  8. Li, L., Zhao, S., Yue, G.G.L., Wong, T.P., Pu, J.X., Sun, H.D., Fung, K.P., Leung, P.C., Han, Q.B., Lau C.B.S., & Leung, P.S. (2018). Isodon eriocalyx and its bioactive component Eriocalyxin B enhance cytotoxic and apoptotic effects of gemcitabine in pancreatic cancer. Phytomedicine, 44, 56-64.
  9. Zhou X., Cao C.Y., Wan A.T.Y., Yue, G.G.L., Kwok F. H.F., Fung, K.P., Sun H.D., Lau C.B.S., Puno P.T., & Tsui S.K.W. (2018). Functional roles of eriocalyxin B in zebrafish revealed by transcriptome analysis. Molecular Omics, 14 (3), 156-169.
  10. Cheung, D.W.S., Koon, C.M., Wong, P.H., Yau, K.C., Wat, E., Hung, A.S., Wang, Y.P., Lau, K.M., Ko, C.H., Chan, J.Y.W., Waye, M.M.Y., & Fung, K.P. (2017). Evaluating Efficacy and Safety of Combination Medication of Atorvastatin and a Herbal Formula Containing Salvia miltiorrhiza and Pueraria lobata on Hyperlipidemia. Phytotherapy Research, 31, 1579–1589.
  11. Zhou, X., Yue, G.G.L., Chan, A.M., Tsui, S.K.W., Fung, K.P., Sun, H., Pu, J., & Lau, C.B.S. (2017). Eriocalyxin B, a novel autophagy inducer, exerts anti-tumor activity through the suppression of Akt/mTOR/p70S6K signaling pathway in breast cancer. Biochemical Pharmacology, 142, 58-70.
  12. Yu, C.O.L., Leung, K.S., Fung, K.P., Lam, F.F.Y., Ng, E.S.K., Lau, K.M., Chow, S.K.H., & Cheung, W.H. (2017). The characterization of a full-thickness excision open foot wound model in n5-streptozotocin (STZ)-induced type 2 diabetic rats that mimics diabetic foot ulcer in terms of reduced blood circulation, higher C-reactive protein, elevated inflammation, and reduced cell proliferation. Experimental Animals, 66(3), 259–269.
  13. Liu, X.Z., Campanac, E., Cheung, H.H., Ziats, M.N., Canterel-Thouennon, L., Raygada, M., Baxendale, V., Pang, A.L.Y., Yang, L., Swedo, S., Thurm, A., Lee, T.L., Fung, K.P., Chan, W.Y., Hoffman, D.A., & Rennert, O.M. (2017). Idiopathic Autism: Cellular and Molecular Phenotypes in Pluripotent Stem Cell-derived Neurons. Molecular Neurobiology, 54(6), 4507-4523.
  14. Xiang, J., Wang, Z., Liu, Q., Li, X., Sun, J., Fung, K.P., & Liu, F. (2017). DMFC (3,5-dimethyl-7H-furo[3,2-g]chromen-7-one) regulates Bim to trigger Bax and Bak activation to suppress drug-resistant human hepatoma. Apoptosis, 22, 381-392.
  15. Li, M., Song, L.H., Yue, G.G., Lee, J.K., Zhao, L.M., Li, L., Zhou, X., Tsui, S.K., Ng, S.S., Fung, K.P., Tan, N.H., & Lau, C.B.S. (2017). Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species. Scientific Reports, 7, 42176.
  16. Chu, C.Y., Tang, L.Y., Li, L., Shum, A.S.W., Fung, K.P., & Wang, C.C. (2017). Adverse Reproductive Effects of Maternal Low-Dose Melamine Exposure During Pregnancy in Rats. Environmental Toxicology, 32(1), 131-138.
  17. Sun, J.G., Ruan, F., Zeng, X.L., Xiang, J., Li, X., Wu, P., Fung, K.P., & Liu, F.Y. (2016). Clitocine Potentiates TRAIL-medicated Apoptosis in Human Colon Cancer Cells by Promoting Mcl-1 Degradation. Apoptosis, 21, 1144-1157.
  18. Zhou, X.N., Yue, G.G.L., Liu, M.H., Zuo, Z.L., Lee, J.K.M., Li, M.Y., Tsui, S.K.W., Fung, K.P., Sun, H.D., Pu, J.X., & Lau, C.B.S. (2016). Eriocalyxin B, a Natural Diterpenoid, Inhibited VEGF-induced Angiogenesis and Diminished Angiogenesis-dependent Breast Tumor Growth by Suppressing VEGFR-2 signaling. Oncotarget, 7(50), 82820-82835.
  19. Yue, G.G.L., Kwok, H.F., Lee, J.K.M., Jiang, L., Wong, E.C.W., Gao, S., Wong, H.L., Li, L., Chan, K.M., Leung, P.C., Fung, K.P., Zuo, Z., & Lau, B.S.C. (2016). Combined Therapy Using Bevacizumab and Turmeric Ethanolic Extract (with Absorbable Curcumin) Exhibited Beneficial Efficacy in Colon Cancer Mice. Pharmacological Research, 111, 43-57.
  20. Wei, W., Xiao, H.T., Bao, W.R., Ma, D.L., Leung, C.H., Han, X.Q., Ko, C.H., Lau, C.B.S., Wong, C.K., Fung, K.P., Leung, P.C., Bian, Z.X., & Han, Q.B. (2016). TLR-4 may Mediate Signaling Pathways of Astragalus Polysaccharide RAP Induced Cytokine Expression of RAW264.7 Cells. Journal of Ethnopharmacology, 179, 243-252.
  21. Wang, Y.P., Wat, E., Koon, C.M., Wong, C.W., Cheung, D.W.S., Leung, P.C., Zhao, Q.S., Fung, K.P., & Lau, C.B.S. (2016). The Beneficial Potential of Polyphenol-enriched Fraction from Erigerontis Herba on Metbolic Syndrome. Journal of Ethnopharmacology, 187, 94-103.
  22. Ng, C.F., Ko, C.H., Koon, C.M., Chin, W.C., Kwong, H.C.S.T., Lo, A.W.I., Wong, H.L., Fung, K.P., Lau, C.B.S., Lam, P.K., Poon, W.S., & Leung, P.C. (2016). The Aqueous Extract of Rhizome of Gastrodia elata Blume Attenuates Locomotor Defect and Inflammation after Traumatic Brain Injury in Rats. Journal of Ethnopharmacology, 185, 87-95.
  23. Yue, G.G.L., Lee, J.K.M., Li, L., Chan, K.M., Wong, E.C.W., Chan, J.Y.W., Fung, K.P., Lui, V.W.Y., Chiu, P.W.Y., & Lau, C.B.S. (2015). Andrographis paniculata elicits anti-invasion activities by suppressing TM4SF3 gene expression and by anoikis-sensitization in esophageal cancer cells. American Journal of Cancer Research, 5, 3570-3587.
  24. Lau, C.B.S., Yue, G.G.L., Fung, K.P., Tan, N.H., & Leung, P.C. (2015). The potential role of chinese herbal medicines in cancer management. Science, 347 (6219 Suppl), S45-S47.
  25. Chan, B.C.L, Han, X.Q., Lui, S.L., Wong, C.W., Wang, T.B.Y., Cheung, D.W.S., Cheng, S.W., Ip, M., Han, S.Q.B., Yang, X.S., Jolivalt, C., Lau, C.B.S., Leung, P.C., & Fung, K.P. (2015). Combating against methicillin-resistant staphylococcus aureus – two fatty acids from purslane (Portulaca oleracea L.) exhibit synergistic effects with erythromycin. Journal of Pharmacy and Pharmacology, 67, 107-116.
  26. Sun, J.G., Xiang, J., Zeng, X.L., Li, X., Wu, P., & Fung, K.P. (2014). Clitocine induces apoptosis and enhances the lethality of ABT-737 in human colon cancer cells by disrupting the interaction of Mcl-1. Cancer Letters, 355, 253-263.
  27. Koon, C.M., Fong, S., Wat, E., Wang, Y.P., Cheung, D.W.S., Lau, C.B.S., Leung, P.C., Sun, H.D., Zhao, Q.S., & Fung, K.P. (2014). Mechanisms of the dilator action of the Erigerontis Herba on rat aorta. J. Ethnopharmacology, 155, 1561-1567.
  28. Cheung, K.K.Y., Chan, J.Y, & Fung, K.P. (2013). Antiproliferative effect of pheophorbide a-medicated photodynamic therapy and its synergistic effect with doxorubicin on multiple drug-resistant uterine sarcoma cell MES-SA/Dx5. Drug and Chemical Toxicology, 36, 474-483.
  29. Hu, F., Chan, J.Y.W., Koon, C.M., & Fung, K.P. (2013). Angiogenic effects of Danshen and Gegen decoction on human endothelial cells and zebra fish embryos. The American Journal of Chinese Medicine, 41, 887-900.
  30. Cheung, D.W.S., Koon, C.M., Wat, E., Ko, C.H., Chan, J.Y.W., Yew, D.T.W., Leung, P.C., Chan, W.Y., Lau, C.B.S., & Fung, K.P. (2013). A herbal formula containing roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibits inflammatory mediators in LPS-stimulated RAW 264.7 macrophages through inhibition of nuclear factor κB (NFκB) pathway. J. Ethnopharmacology, 145(3), 776-783.