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Research Interests: Epithelial transport, Purine and pyrimidine receptors, Calcium signalling, Confocal microscopy
My research mainly focuses on (i) the control of fluid and electrolyte transport by mammalian epithelial cells and the physiological basis of diseases such as cystic fibrosis, male infertility, equine anhidrosis and secretory diahorrea, that are characterised by dysfunction of these processes; and (ii) the interactions between different signalling pathways (e.g. cAMP, Ca) and intracellular pH (pHi), and the role of which they may play in controlling the activity of epithelial ion channels. Various techniques such as tissue culture, radioimmunoassay, short-circuit current measurement, microspectrofluorimetry, and confocal imaging microscopy are employed to explore physiological problems.
Selected Publications:
* Ko, W.H., O'Dowd, J.J.M., Pediani, J.D., Bovell, D.L., Elder, H.Y., Jenkinson, D.McE., Wilson, S.M. Extracellular ATP can activate autonomic signal transduction pathways in cultured equine sweat gland epithelial cells. Journal of Experimental Biology 190, 239-252, 1994.
* Ko, W.H., Pediani, J.D., Bovell, D.L. & Wilson, S.M. Sr can become incorporated into an agonist-sensitive, cytoplasmic Ca store in a cell line derived from the equine sweat gland epithelium. Experientia 51,804-808, 1995.
* Ko, W.H., Chan, H.C., Chew, S.B.C. and Wong, P.Y.D. Ionic mechanisms of Ca-dependent electrolyte transport across equine sweat gland epithelium. Journal of Physiology 493(3), 885-894, 1996. (A figure has been chosen for the front cover picture of the Journal.)
* Ko, W.H., Chan, H.C. and Wong, P.Y.D. Anion secretion induced by capacitative Ca entry via apical and basolateral membranes of cultured equine sweat gland epithelium. Journal of Physiology 497(1), 19-29, 1996.
* Ko, W.H., S.M. Wilson. and Wong, P.Y.D. Receptors for purine and pyrimidine nucleotides in the apical membranes of cultured equine epithelial cells. British Journal of Pharmacology 121, 150-156, 1997.
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