Professor Dennis Lo
Professor Rossa Chiu
Professor Allen K C Chan
Professor Nelson Tang
Professor Chun Kwok Wong
Professor Kathy Lui
Professor Sung Wing Kin
Professor Peiyong Jiang
Professor Peter Cheung
Professor Hei Ming Lai
Professor Jacky Lam
Professor Guanhua Zhu
Professor Chun Kit Choi
Professor Mingyuan Li
Professor Qing Zhou
Professor Nirmal Panesar
Professor Chung Shun Ho
Dr Michael H M Chan
Dr Jeffrey SS Kwok
 
 
 
Chun Kwok Wong 黃振國
Professor 教授
ck-wong@cuhk.edu.hk
https://sites.google.com/view/ckwgroup/home
Biography
Professor Wong is currently Professor in Department of Chemical Pathology, Director of Institute of Chinese Medicine and Assistant Director of State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, CUHK. He obtained his PhD degree in Immunology from the Department of Biochemistry, CUHK in 1993. This was followed by postdoctoral appointments at the Centre for Biochemical and Biophysical Science and Medicine of the Brigham and Women's Hospital, Harvard Medical School (1994-1996), and the Pulmonary and Critical Care Unit at the Massachusetts General Hospital, Harvard Medical School, USA (1996-1997). He was appointed postdoctoral research fellow in the Department of Chemical Pathology, CUHK from August 1997 to June 2000, Scientific Officer in July 2000, Associate Professor in February 2001, and Professor in August 2009.
 
Professor Wong is involved in teaching medical students (including Chinese Medicine students) and students of School of Biomedical Sciences, Faculty of Medicine and MSc course, School of Life Sciences. Currently, Professor Wong is supervising six full-time PhD students. He also serves as Honorary Scientific Officer (Medical) in the diagnostic clinical chemistry laboratory at Prince of Wales Hospital.
 
Professor Wong was the former President of Hong Kong Society for Immunology and Hong Kong Society of Flow Cytometry, current Treasurer of the Hong Kong Society for Immunology and Hong Kong Society of Flow Cytometry, and Fellow of Royal Society of Biology (FRSB), UK.
Research Interests:
His immunology research includes (1) the elucidation of cytokine and chemokine network and intracellular signal transductions of immune effector cells including eosinophils, lymphocytes, mast cells, basophils and dendritic cells in inflammatory diseases, with recent emphasizing in the translational application of immunoregulatory cytokines, (2) the immunopathological mechanisms of allergic diseases, autoimmune diseases and infectious diseases, with interdepartmental collaboration and (3) the immunomodulatory, anti-infectious, anti-tumor and anti-allergic activities of traditional Chinese medicine and natural products. High-throughput immunoassay, multiparametric flow cytometry, mass cytometry, multiplex immunofluorescence assay for spatial analysis, single-cell RNA sequencing, proteomic method and transgenic murine model have been applied in above studies. He has published over 290 refereed papers in international journals and book chapters (Web of Science Core Collection, H-index = 56).
Illustrations of the 2 major research areas:
(1) Cytokine and chemokine network of inflammatory diseases
(2) Intracellular signal transductions in immune effector cells
 
 
 
 
 
 
Ten Representative Publications in 2015-2024:
Dong J, Wong CK (correspondence author), Cai Z, Jiao D, Chu M and Lam CWK. Amelioration of allergic airway inflammation in mice by regulatory IL-35 through dampening inflammatory dendritic cells. Allergy 2015; 70: 921-932.
Jiao D, Wong CK (correspondence author), Qiu HN, Dong J, Cai Z, Chu M, Hon KL, Tsang MSM, Lam CWK. NOD2 and TLR2 ligands trigger the activation of basophils and eosinophils by interacting with dermal fibroblasts in atopic dermatitis-like skin inflammation. Cell Mol Immunol 2016; 13: 535-550.
Hou T, Sun X, Zhu J, Hon KL, Jiang P, Chu IM, Tsang MS, Lam CW, Zeng H, Wong CK (correspondence author). IL-37 ameliorating allergic inflammation in atopic dermatitis through regulating microbiota and AMPK-mTOR signaling pathway-modulated autophagy mechanism. 2020. Front Immunol 2020; 11: 752.
Sun X, Hou T, Cheung EC, Iu TN, Tam VW, Chu IM, Tsang MS, Chan PK, Lam CW, Wong CK (correspondence author). Anti-inflammatory Mechanisms of the Novel Cytokine Interleukin-38 in Allergic Asthma. Cell Mol Immunol 2020; 17:631-646.
Hou T, Tsang MSM, Chu IMT, Kan LL, Hon KL, Leung TF, Lam CWK and Wong CK (correspondence Author). Skewed Inflammation is associated with aberrant interleukin-37 signaling pathway in atopic dermatitis. Allergy 2021; 76: 2102-2114.
Cai Z, Zhang S, Wu P , Ren Q, Wei P, Hong M, Feng Y, Wong CK (correspondence author), Tang H, Zeng H. A novel potential target of IL-35 regulated JAK/STAT signaling pathway in lupus nephritis. Clin Transl Med 2021; 11:e309.
Gao X, Chan PKS, Lui GCY, Hui DSC, Chu IMT, Sun X, Tsang MSM, Chan BCL, Lam CWK and Wong CK (correspondence author). Interleukin-38 ameliorates Poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infections. Cell Death and Disease 2021; 12:53.
Lui G, Wong CK (Equal first author), Chan M, Chong KC, Wong R, Chu I, Zhang M, Li T, Hui D, Lee N, Chan P. Host inflammatory response is the major marker of severe respiratory syncytial virus infection in older adults. J Infection 2021; 83:686-692.
Gao X, Leung TF, Wong GW, Ko WH, Cai M, He EJ, Chu IMT, Tsang MS, Chan BC, Ling J, Fan X, Lu L, Lam CW and Wong CK (correspondence author). Meteorin-β/Meteorin like/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma Cell Mol Immunol 2022; 19:245-259.
Huang D, Liu X, Gao X, Choi CK, Giglio G, Farah L, Leung TF, Wong KC, Kan LL, Chong JW, Meng QJ, Liao J, Cheung PF, Wong CK (correspondence author). Meteorin-like protein/METRNL/Interleukin-41 ameliorates atopic dermatitis-like inflammation. Allergy 2024; doi: 10.1111/all.16150.