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| Biography |
Dr. Hei Ming Lai was a psychiatrist-neuroscientist and is now a clinical assistant professor in the Department of Chemical Pathology, CUHK. With a broad interest in multiple disciplines from chemistry to psychiatry, Dr Lai’s team developed novel technologies to discover new biological principles. His team’s inventions have been featured on renowned journal covers and recognized by 3 gold medals or above in the International Exhibition of Inventions Geneva. His current research interests include 3D histology-based precision medicine, biotechnology, biophysics, and neuropsychopharmacology. |
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Specialised Research Area(s):
- 3D Histology: Engineering scalable, high-throughput pipelines for revolutionizing pathology and tissue-based research.
- Biotechnology: Developing general strategies to augment protein functions in native or alien contexts.
- Biophysics: Understanding how tissue structures and molecules correlate with their (dys)functions.
- Neuropsychopharmacology: Identifying brain regions and cell types underlying psychiatric drug mechanisms.
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Selected publications: |
Yau JCN*, Lai HM*†, Lee K, Kwok AJ, Huang J, Ko H†. Principles of Deep Immunohistochemistry for 3D Histology. Cell Reports Methods. 2023 Apr 20; 3:100458. https://doi.org/10.1016/j.crmeth.2023.100458. Journal IF: 3.8. (*co-first authors; †co-corresponding authors). |
Lai HM*†, Tang Y*, Lau ZYH*, Campbell RAA, Yau JCN, Chan CCY, Chan DCW, Wong TY, Wong HKT, Yan LYC, Wu WKK, Wong SH, Kwok KW, Wing YK, Lam HHN, Ng HK, Mrsic-Flogel TD, Mok VCT, Chan JYK, Ko H†. Antibody stabilization for thermally accelerated deep immunostaining. Nature Methods. 2022 Sept 1; 19:1137-1146. https://www.nature.com/articles/s41592-022-01569-1. Journal IF: 47.990. (*co-first authors; †co-corresponding authors). |
Lai HM*†, Lu Z*, Choi CK*, Zhou W, Yau JCN, Tang BZ, Ko H†. Direct room temperature synthesis of α-CsPbI3 perovskite nanocrystals with high photoluminescence quantum yields: implications for lighting and photovoltaic applications. ACS Applied Nano Materials. 2022 Apr 27;5(9):12366-112373. https://pubs.acs.org/doi/10.1021/acsanm.2c00732. Journal IF: 6.14. (*co-first authors; †co-corresponding authors). |
Lo HS*, Hui K*, Lai HM*, Khan K, Kaur S, Huang J, Li Z, Chan A, Cheung H, Ng KC, Ho J, Chen YW, Ma B, Cheung P, Shin D, Wang K, Lee MH, Selisko B, Eydoux C, Guillemot JC, Canard B, Wu KP, Liang PH, Dikic I, Zuo Z, Chan FKL, Hui DSC, Mok VCT, Wong KB, Mok C, Ko H, Aik WS, Chan M, Ng WL. Simeprevir potently suppresses SARS-CoV-2 replication and synergizes with remdesivir. ACS Central Science. 2021 Apr 15;7(5):792-802. https://pubs.acs.org/doi/10.1021/acscentsci.0c01186. Journal IF: 18.728. (*co-first authors). |
Lee K*, Lai HM*†, Soerensen M, Hui E, Cho W, Ma V, Ho J, Chang RCCC†. Optimized Tissue Clearing Minimizes Distortion and Destruction During Tissue Delipidation. Neuropathology and Applied Neurobiology. 2020 Dec 2;47(3):441-453. https://onlinelibrary.wiley.com/doi/10.1111/nan.12673. Journal IF: 6.250. (*co-first authors; †co-corresponding authors). |
Lai HM*, Liu AKLL*, Ng HHM*, Goldfinger, MH, Chau, TW, DeFelice J, Tilley BS, Wong WM, Wu W, Gentleman SM. Next generation histology methods for three-dimensional imaging of fresh and archival human brain tissues. Nature Communications. 2018 Mar 14;9(1):1066. https://www.nature.com/articles/s41467-018-03359-w. Journal IF: 17.694. (*co-first authors). |
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