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| Biography |
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Dr. Jacky Lam is the Assistant Professor of the Department of Chemical Pathology and an honorary associate consultant at the Prince of Wales Hospital. Dr. Lam obtained his medical degree in 2007 and received his Ph.D. in Chemical Pathology from the Chinese University of Hong Kong in 2020. His research interests are on the biological features of plasma DNA and its potential clinical application in noninvasive cancer detection. He is involved in a large-scale prospective clinical study using plasma Epstein-Barr virus DNA for screening of nasopharyngeal carcinoma. This study laid the foundation for the clinical utility of plasma Epstein-Barr virus DNA analysis for cancer screening. Based on this study, he has further investigated the distinct molecular features of plasma Epstein-Barr virus DNA in nasopharyngeal cancer. Such discoveries have led to the development of novel diagnostic assays which allows better differentiation of patients with nasopharyngeal cancer and non-cancer subjects in the context of screening. |
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| Specialized Research Area(s): |
| 1. Non-invasive cancer diagnostic approaches |
| 2. Biology of circulating nucleic acids |
3. Nasopharyngeal cancer diagnostics |
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Selected publications: |
KCA Chan, WKJ Lam, AD King, VS Lin, PPH Lee, BCY Zee, SL Chan, IOL Tse, AFC Tsang, MZJ Li, P Jiang, QYH Ai, DMC Poon, KH Au, EP Hui, BBY Ma, AC van Hasselt, ATC Chan, JKS Woo, YMD Lo. Plasma Epstein-Barr virus DNA and risk of future nasopharyngeal cancer. New England Journal of Medicine Evidence. 2023; 2(7). https://evidence.nejm.org/doi/full/10.1056/EVIDoa2200309 |
PJ Lou, WKJ Lam* (co-first author), WL Hsu, RM Pfeiffer, KJ Yu, CML Chan, VCT Lee, TC Chen, SD Terng, YA Tsou, YS Leu, LJ Liao, YL Chang, YC Chien, CP Wang, CY Lin, CH Hua, JC Lee, TL Yang, CH Hsiao, MS Wu, MH Tsai, HC Cheng, A Hildesheim, CJ Chen, KCA Chan, Z Liu. Performance and operational feasibility of Epstein-Barr virus-based screening for detection of nasopharyngeal carcinoma: Direct comparison of two alternative approaches. Journal of Clinical Oncology. 2023; JCO2201979. https://ascopubs.org/doi/10.1200/JCO.22.01979 |
WKJ Lam*, AD King, JA Miller, Z Liu, KJ Yu, MLK Chua, BBY Ma, MY Chen, BA Pinsky, PJ Lou, JKS Woo, WL Hsu, J Simon, DL Doolan, T Waterboer, EP Hui, H Li, RK Tsang, KCW Wong, JP Goh, AC Vlantis, QY Ai, LM Wong, V Abdullah, JC Lin, CJ Chen, RM Pfeiffer, QT Le, AWM Lee, MF Ji, SM Cao, J Ma, ATC Chan, KCA Chan, A Hildesheim. Recommendations for Epstein-Barr virus-based screening for nasopharyngeal cancer in high- and intermediate-risk regions. Journal of National Cancer Institute 2023; doi:10/1093/jnci/djad012. https://academic.oup.com/jnci/article/115/4/355/7020056 |
G Wang, WKJ Lam* (co-first author), L Ling, MJL Ma, S Ramakrishnan, DCT Chan, WS Lee, SH Cheng, RWY Chan, SCY Yu, IOL Tse, WT Wong, P Jiang, RWK Chiu, KCA Chan, YMD Lo. Fragment ends of circulating microbial DNA as signatures for pathogen detection in sepsis. Clinical Chemistry. 2023;69(2):189-201. https://academic.oup.com/clinchem/article/69/2/189/6964494 |
DCT Chan, WKJ Lam* (co-first author), EP Hui, BBY Ma, CML Chan, VCT Lee, SH Cheng, W Gai, P Jiang, KCW Wong, F Mo, B Zee, AD King, QT Le, ATC Chan, KCA Chan, YMD Lo. Improved risk stratification of nasopharyngeal cancer by targeted sequencing of Epstein-Barr virus DNA in post-treatment plasma. Annals of Oncology. 2022;33(8):794-803. https://www.annalsofoncology.org/article/S0923-7534(22)00753-0/fulltext |
KCW Wong, EP Hui, KW Lo, WKJ Lam, D Johnson, L Li, Q Tao, KCA Chan, KF To, AD King, BBY Ma, ATC Chan. Nasopharyngeal carcinoma: an evolving paradigm. Nature Reviews Clinical Oncology. 2021;18(11):679-695. https://www.nature.com/articles/s41571-021-00524-x |
EP Hui, BBY Ma, WKJ Lam, KCA Chan, F Mo, QYH Ai, AD King, CH Wong, KCW Wong, DCM Lam, M Tong, DMC Poon, L Li, TKH Lau, KH Wong, YMD Lo, ATC Chan. Dynamic changes of post-radiotherapy plasma Epstein-Barr virus DNA in a randomized trial of adjuvant chemotherapy versus observation in nasopharyngeal cancer. Clinical Cancer Research. 2021;27(10):2827-2836. https://aacrjournals.org/clincancerres/article/27/10/2827/665673/Dynamic-Changes-of-Post-Radiotherapy-Plasma |
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WKJ Lam*, L Ji, OYO Tse, SH Cheng, P Jiang, PHP Lee, SV Lin, EP Hui, BBY Ma, ATC Chan, KCA Chan, RWK Chiu, YMD Lo. Sequencing analysis of plasma Epstein-Barr virus DNA reveals nasopharyngeal carcinoma-associated single nucleotide variant profiles. Clinical Chemistry. 2020;66(4):598-605. https://academic.oup.com/clinchem/article/66/4/598/5810133 |
WKJ Lam*, P Jiang, KCA Chan, W Peng, H Shang, MMS Heung, SH Cheng, H Zhang, OYO Tse, R Raghupathy, BBY Ma, EP Hui, ATC Chan, JKS Woo, RWK Chiu, YMD Lo. Methylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases. Nature Communications. 2019;10(1):3256. https://www.nature.com/articles/s41467-019-11226-5 |
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WKJ Lam*, P Jiang, KCA Chan, SH Cheng, H Zhang, W Peng, OYO Tse, YK Tong, W Gai, BCY Zee, BBY Ma, EP Hui, ATC Chan, JKS Woo, RWK Chiu, YMD Lo. Sequencing-based counting and size profiling of plasma Epstein-Barr virus DNA enhance population screening of nasopharyngeal carcinoma. Proceedings of the National Academy of Sciences of the United States of America. 2018;115(22):E5115-E2124. https://pathsocjournals.onlinelibrary.wiley.com/doi/full/10.1002/path.5249 |
KCA Chan, JKS Woo, A King, BCY Zee, WKJ Lam, SL Chan, SWI Chu, C Mak, IOL Tse, SYM Leung, G Chan, EP Hui, BBY Ma, RWK Chiu, S Leung, AC van Hasselt, ATC Chan, YMD Lo. Analysis of plasma Epstein-Barr virus DNA to screen for nasopharyngeal carcinoma. New England Journal of Medicine. 2017;377(6):513-522. https://www.nejm.org/doi/full/10.1056/nejmoa1701717 |
WKJ Lam*, W Gai, K Sun, RSM Wong, RWY Chan, P Jiang, NPH Chan, WWI Hui, AWH Chan, CC Szeto, SC Ng, MF Law, KCA Chan, RWK Chiu, YMD Lo. DNA of erythroid origin is present in human plasma and informs the types of anemia. Clinical Chemistry. 2017;63(10):1614-1623. https://academic.oup.com/clinchem/article/63/10/1614/5612682 |
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